Molecular basis for mitochondrial signaling
著者
書誌事項
Molecular basis for mitochondrial signaling
(Biological and medical physics, biomedical engineering)
Springer, c2017
大学図書館所蔵 全3件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.
目次
- Mitochondrial Calcium Signaling.- Systems approaches to mitochondrial calcium signaling.- The mitochondrial Calcium Uniporter: Molecular Composition And Physiological Role.- Molecular Mechanisms of Mitochondrial Ca2+ Uptake.- Ca2+ uniporter and male fertility.- The Mitochondrial Permeability Transition pore: Finally Structure Meets Function.- ATP synthase forms the Mitochondrial Permeability Transition Pore.- C-subunit ring of the ATP synthase is the mitochondrial permeability transition pore.- Mitochondrial Outer Membrane Transport Systems: Structure, Function, and Physiological Implications.- VDAC and tubulin in regulation of mitochondrial metabolism.- Warburg revised: regulation of mitochondrial metabolism by VDAC in cancer cells.- VDAC isoforms in mammals.- Plant VDAC: function, structure, computational studies.- VDAC 1, 2 structure and structure-guided simulations of ATP translocation and VDAC gating.- MD simulations of VDAC selectivity and gating.- TSPO interacts with VDAC1 and triggers a ROS mediated inhibition of mitochondrial quality control.- VDAC/Hexokinase complex as a generator of the mitochondrial outer membrane potential.- TOM complex, Tom40 - protein translocator complex of the mitochondrial outer membrane.- Mitochondria And Cellular Signaling Network.- Mitochondrial Interactosome: mitochondria and cytoskeleton
- cardiac mitochondria.- Mitochondrial respiration and ROS.- Diversity of Mitochondria Outer Membrane Permeabilization (MOMP) Pathways: Structure and Mechanism.- Molecular identity of mitochondrial apoptosis-induced channels (MAC).- Ceramide channels in the mitochondrial outer membrane.- Bax regulates ceramide synthase and ceramide-induced apoptosis.- Biophysical changes in bilayer properties following Bax insertion into a membrane.- A new view of the lethal apoptotic pore (Bax).- Other Mitochondrial Channels.- K(ATP) channels in the inner membrane.
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