Prion protein
著者
書誌事項
Prion protein
（Progress in molecular biology and translational science, v. 150）
Academic Press, an imprint of Elsevier, 2017
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Prion Protein, Volume 150, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on Prion Protein, a protein that is considered to be the archetype of intrinsically disordered proteins. This updated volume includes comprehensive sections on a variety of timely topics, including Functions of Prion Protein, Copper and Prion protein, Cell Biology of Prion Protein, Structural Studies of Prion Proteins, Molecular Simulations on Wild Type and Mutant Prion Proteins, Genetics of Prion Protein, The Prion Concept and Synthetic Prions, and Transgenic Mouse Models.
As neurodegenerative diseases represent a health issue that is receiving increasing attention from the scientific community due to their social and economic impact, this series is an ideal resource for the latest research in molecular biology and translational science.
目次
1. Functions of the Prion Protein Theo Z. Hirsch, Severine Martin-Lanneree and Sophie Mouillet-Richard 2. Copper- and Zinc-Promoted Interdomain Structure in the Prion Protein: A Mechanism for Autoinhibition of the Neurotoxic N-Terminus Eric G.B. Evans and Glenn L. Millhauser 3. Cell Biology of Prion Protein Daniela Sarnataro, Anna Pepe and Chiara Zurzolo 4. Understanding the Effect of Disease-Related Mutations on Human Prion Protein Structure: Insights From NMR Spectroscopy Ivana Biljan, Gregor Ilc and Janez Plavec 5. Structural Modeling of Human Prion Protein's Point Mutations Giulia Rossetti and Paolo Carloni 6. Prion Protein and Genetic Susceptibility to Diseases Caused by Its Misfolding George A. Carlson 7. The Prion Concept and Synthetic Prions Giuseppe Legname and Fabio Moda 8. Gene Targeted Transgenic Mouse Models in Prion Research Abigail B. Diack, James D. Alibhai and Jean C. Manson 9. Transmission and Replication of Prions A. Marin-Moreno, N. Fernandez-Borges, J.C. Espinosa, O. Andreoletti and J.M. Torres 10. Immunology of Prion Protein and Prions Neil A. Mabbott 11. Phenotypical Variability in Bovine Spongiform Encephalopathy: Epidemiology, Pathogenesis, and Diagnosis of Classical and Atypical Forms Cristiano Corona, Elena V. Costassa, Barbara Iulini, Elena Bozzetta, Maria Mazza, Rosanna Desiato, Giuseppe Ru and Cristina Casalone 12. Scrapie, CWD, and Transmissible Spongiform Encephalopathy Candace K. Mathiason 13. Infectious and Sporadic Prion Diseases Richard Knight 14. Neuropathology of Human Prion Diseases Diane L. Ritchie and James W. Ironside 15. The Structure of the Infectious Prion Protein and Its Propagation Jesus R. Requena and Holger Wille 16. Protein Misfolding Cyclic Amplification of Infectious Prions Fabio Moda 17. Amplified Detection of Prions and Other Amyloids by RT-QuIC in Diagnostics and the Evaluation of Therapeutics and Disinfectants Byron Caughey, Christina D. Orru, Bradley R. Groveman, Andrew G. Hughson, Matteo Manca, Lynne D. Raymond, Gregory J. Raymond, Brent Race, Eri Saijo and Allison Kraus 18. Biochemical Characterization of Prions Michele Fiorini, Matilde Bongianni, Salvatore Monaco and Gianluigi Zanusso 19. Omics of Prion Diseases Silvia Vanni 20. Therapeutic Approaches to Prion Diseases Annachiara Gandini and Maria L. Bolognesi 21. Biosafety of Prions Edoardo Bistaffa, Martina Rossi, Chiara M.G. De Luca and Fabio Moda
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