Patient-derived mouse models of cancer : patient-derived orthotopic xenografts (PDOX)
著者
書誌事項
Patient-derived mouse models of cancer : patient-derived orthotopic xenografts (PDOX)
（Molecular and translational medicine / series editors, William B. Coleman, Gregory J. Tsongalis）
Humana Press, 2017
- hbk.
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内容説明・目次
内容説明
This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section.
Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems
目次
1. In memorium: Jorgen Rygaard (1934-2016) Father of patient derived mouse models of cancer and modern cancer research.
2. The revival of patient-derived mouse models of cancer: way back to the future
3. Patient-derived xenograft models for human cancer, The Freiburg experience
4. From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype
5. The Effects of the Organ Microenvironment on Metastatic-Cell Gene Signatures
6. Techniques for surgical orthotopic implantation of human tumors to immunodeficient mice
7. The first patient-derived orthotopic xenograft (PDOX) mouse models of cancer: Cancer of the colon, pancreas, lung, breast, ovary, and mesothelioma
8. Patient-derived xenograft models of prostate cancer
9. Patient-Derived Mouse Models of Sarcoma
10. Cervical cancer patient-derived orthotopic xenograft (PDOX) models
11. The use of pediatric patient-derived xenografts for identifying novel agents and combinations
12. Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics
13. Use of patient-derived orthotopic xenografts (PDOX) to evaluate transformative cancer therapeutics
14. Fluorescent protein-expressing transgenic nude mice as hosts for patient tumors
15. Fluorescence imaging of tumors in human patient-derived orthotopic xenograft (PDOX) mouse models: The iPDOX model
16. The use of patient-derived orthotopic xenograft (PDOX) models to develop curative fluorescence-guided surgery of cancer
17. Molecular characteristics of patient-derived tumor xenografts: genomic similarity to patient tumors and relevance for biomarker discovery
18. Complementarity of patient-derived orthotopic xenografts (PDOX) models and molecular profiling for optimal therapy
19. 3D Cell Culture Models
20. Why patient derived mouse models need to be orthotopic
21. Foreward: The future of patient-derived models of cancer
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