Therapeutic peptides and proteins : formulation, processing, and delivery systems
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Bibliographic Information
Therapeutic peptides and proteins : formulation, processing, and delivery systems
CRC Press, c2015
3rd ed
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis.
The clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable, and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, microbiology, and chemical engineering and needs to keep abreast with the latest research in the published literature.
Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Third Edition provides a comprehensive overview of the field for scientists in industry and academia and for students, while also providing practical information on the challenges facing the formulation and delivery aspects of these unique macromolecules. In particular, the book:
Explains how recombinant DNA techniques now allow us to produce therapeutic proteins in a commercially viable form
Discusses the physical and chemical pathways of peptide and protein degradation
Includes a detailed discussion of protein formulation and lyophilization
Overviews the pharmacokinetic aspects of therapeutic peptides and proteins and discusses controlled delivery systems for parenteral administration, including microsphere formulations
Discusses research progress on oral, transdermal, mucosal, and topical delivery systems discusses transdermal and topical delivery
Table of Contents
Formulation and Processing. Pharmaceutical Biotechnology: The Arrival of Recombinant Proteins. What is Biotechnology ? Structure and Analysis of Therapeutic Peptides and Proteins. Stability of Therapeutic Peptides and Proteins. Preformulation and Formulation of Therapeutic Peptides and Proteins. Lyophilization, Pharmaceutical Processing and Handling of Therapeutic Peptides and Proteins. Drug Delivery Systems. Parenteral Controlled Delivery of Therapeutic Peptides and Proteins. Oral Delivery of Therapeutic Peptides and Proteins. Transdermal and Topical Delivery of Therapeutic Peptides and Proteins. Pulmonary and other Mucosal Delivery of Therapeutic Peptides and Proteins. Recombinant Protein Subunit Vaccines and Delivery Methods.
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