Vitamin D
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書誌事項
Vitamin D
Academic Press, an imprint of Elsevier, c2018
4th ed.
- v. 1
- v. 2
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v.1: Biochemistry, physiology and diagnostics
v.2: Health, disease and therapeutics
Includes bibliographical references and index
内容説明・目次
- 巻冊次
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v. 2 ISBN 9780128099636
内容説明
Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, inflammatory bowel disease, multiple sclerosis and renal disease.
This collection represents a who’s who of vitamin D research and the coverage is appropriately broad, drawing in internal medicine, orthopedics, oncology and immunology. Clinical researchers will gain a strong understanding of the molecular basis for a particular area of focus.
目次
Volume II: Health, Disease and Therapeutics
Section VII. Population Studies: Vitamin D Deficiency, Nutrition, Sunlight, Genes & Trials 58. Methods of evaluating population studies of vitamin D: strengths & weaknesses 59. Worldwide vitamin D status 60. Vitamin D in Foods: An Evolution of Knowledge 61. Determinants of Vitamin D Deficiency from Sun Exposure: A Global Perspective 62. Vitamin D Fortification and Supplementation Policies to Correct Vitamin D Insufficiency/Deficiency Globally 63. Vitamin D and Food Fortification 64. Bariatric Surgery, Vitamin D, and Bone Loss 65. Genetics of the Vitamin D Endocrine System 66. Randomized Clinical Trials of Vitamin D for the Primary Prevention of Cancer and Cardiovascular Disease, with a Focus on the VITamin D and OmegA-3 TriaL (VITAL)
Section VIII. Disorders 67. Vitamin D deficiency and nutritional rickets in children 68. Vitamin D and Osteoporosis 69. Adult Vitamin D deficiency: fracture & fall prevention 70. Clinical Disorders of Phosphate Homeostasis 71. Vitamin D hydroxylation-deficient rickets, type 1A: CYP27B1 mutations 72. Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets 73. The Role of Genetic Variation in CYP2R1, the Principal Vitamin D 25-hydroxylase, in Vitamin D Homeostasis 74. Infantile Hypercalcemia and CYP24A1 Mutations 75. Drug and Hormone Effects on Vitamin D Metabolism 76. Vitamin D and Organ Transplantation 77. The role of vitamin D in type 2 diabetes and hypertension 78. Vitamin D, obesity and the metabolic syndrome 79. Vitamin D and Renal Disease 80. Calcitriol and Analogs in the Treatment of Chronic Kidney Disease 81. Idiopathic Hypercalciuria and Nephrolithiasis 82. Hypercalcemia Due to Vitamin D Toxicity 83. The Hypocalcemic Disorders 84. Vitamin D: Cardiovascular Effects and Vascular Calcification 85. Vitamin D and Paget’s Disease
Section IX. Vitamin D Analogs 86. Analogs of Calcitriol 87. Non-Secosteroidal Ligands and Modulators of VDR 88. Bile acid-derived vitamin D receptor ligands 89. Bifunctional Vitamin D Hybrid Molecules 90. Modulating Vitamin D Receptor–Coregulator Binding with Small Molecules 91. Extended-release Calcifediol in Renal Disease 92. Vitamin D Receptor Antagonists 93. Eldecalcitol and Osteoporosis
Section X. Vitamin D and Cancer 94. Overview of vitamin D actions in cancer 95. Vitamin D Status and Cancer Incidence, Mortality and Prognosis 96. Effects of Vitamin D Derivatives on Differentiation, Cell Cycle and Apoptosis in Hematological Malignancies 97. Vitamin D actions in mammary gland and breast cancer: genomics, metabolism and stem cells 98. Vitamin D Urologic Cancers 99. Vitamin D and Colon Cancer 100. Vitamin D and Skin Cancer 101. Vitamin D and Lung Cancer 102. Vitamin D inflammation and cancer
Section XI. Immunity, Inflammation and Disease 103. Vitamin D and Tuberculosis 104. Vitamin D and Adaptive Immunology in Health and Disease 105. Vitamin D and Innate Immunity 106. Vitamin D and Diabetes 107. Vitamin D and Multiple Sclerosis 108. Vitamin D and Inflammatory Bowel Disease 109. Psoriasis and other Skin Diseases
Section XII. Therapeutic Applications and New Advances 110. Sunlight protection by vitamin D compounds 111. Vitamin D, Cardiovascular Disease and Hypertension 112. Vitamin D, Acute Respiratory Infection, and Asthma/COPD 113. Vitamin D and Muscle Performance in Athletes 114. Vitamin D: Presence and Function in the Eye 115. Adult vitamin D deficiency and adverse brain outcomes 116. Vitamin D in Pregnancy and Lactation: Moving into the Future 117. Vitamin D and Critically Ill ICU Patients
- 巻冊次
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v. 1 ISBN 9780128099650
内容説明
Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D.
This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease.
目次
Volume 1: Biochemistry, Physiology and Diagnostics In Memoriam: Robert P. Heaney, MD (1928-2016) In Memoriam: Milan Uskokovic, PhD (1924-2015)
Section I. History, Chemistry Metabolism, Circulation & Regulation 1. Historical Overview of Vitamin D 2. Evolutionary Biology: Mysteries of Vitamin D in Fish 3. Evolution of Human Skin Color and Vitamin D 4. Photobiology of Vitamin D 5. The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases) 6. CYP24A1: Structure, Function, and Physiological Role 7. The Vitamin D Binding Protein DBP 8. Regulation of renal and extra-renal 1a-hydroxylase
Section II. Mechanism of Action 9. Genome-Wide Perspectives on Vitamin D Receptor-Meditated Control of Gene Expression in Target Cells 10. Diverse mechanisms of transcriptional regulation by the vitamin D receptor 11. Structural basis for ligand activity in VDR 12. Ligand Independent Actions of Vitamin D Receptor 13. Vitamin D and Chromatin 14. Mesenchymal Differentiation, Epigenetic Dynamics, and Interactions with VDR 15. Vitamin D and microRNAs 16. Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions
Section III. Mineral and Bone Homeostasis 17. Vitamin D Regulation of Osteoblast Function 18. Osteoclastogenesis and Vitamin D 19. Vitamin D Activities in Osteocytes 20. Regulation of Intestinal Calcium and Phosphate Absorption 21. Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6 22. Calcium homeostasis and eggshell biomineralization in female chicken 23. Mineralization in Mammals 24. Cartilage 25. Vitamin D and Bone: An Integrated Approach
Section IV. Extra-Skeletal Targets 26. Vitamin D and the Kidney 27. Vitamin D and the Parathyroids 28. The Calcium-sensing Receptor and Vitamin D 29. Vitamin D in Dentoalveolar and Oral Health 30. The Role of Vitamin D and its Receptor in Hair Follicle Biology 31. Vitamin D, Calcium and the Epidermis 32. Vitamin D and the Cardiovascular System 33. Vitamin D Brain Development and Function 34. Vitamin D, VDR and Adipose Tissue: Focus on Cellular Mechanisms 35. Vitamin D and Skeletal Muscle 36. Understanding Vitamin D from mouse knockout models
Section V. Human Physiology 37. Pharmacology and pharmacokinetics 38. Vitamin D Role in the Calcium and Phosphorus Economies 39. Fetus, Neonate and Infant 40. Consequences of perinatal vitamin D deficiency on later bone health 41. Adolescence and Acquisition of Peak Bone Mass 42. Pregnancy, Lactation, and Post-Weaning Recovery 43. Role in Reproductive Biology and Reproductive Dysfunction in Women 44. Vitamin D, reproductive biology, and dysfunction in men 45. Vitamin D and the Renin-Angiotensin System 46. Parathyroid Hormone, Parathyroid Hormone-Related Protein, and Calcitonin 47. FGF23 Counter Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and L. Darryl Quarles
Section VI. Diagnosis and Management 48. Approach to the Patient with Metabolic Bone Disease 49. Detection of 1,25-Dihydroxyvitamin D in Human Serum using Receptor Assisted Chemiluminescent Hormone Assay (REACH) Technology 50. Mass Spectrometry Assays of Vitamin D Metabolites 51. Free Vitamin D: Concepts, Assays, Outcomes and Prospects 52. 25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems and Interpretation 53. Bone Histomorphometry 54. Radiology of Rickets and Osteomalcia 55. High-resolution Imaging Techniques for Bone Quality Assessment 56. The Role of Vitamin D in Orthopedic Surgery 57a. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the IOM Position 57b. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position
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