Theoretical molecular biophysics
著者
書誌事項
Theoretical molecular biophysics
(Biological and medical physics, biomedical engineering)
Springer, c2017
2nd ed
大学図書館所蔵 全4件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book gives an introduction to molecular biophysics. It starts from material properties at equilibrium related to polymers, dielectrics and membranes. Electronic spectra are developed for the understanding of elementary dynamic processes in photosynthesis including proton transfer and dynamics of molecular motors. Since the molecular structures of functional groups of bio-systems were resolved, it has become feasible to develop a theory based on the quantum theory and statistical physics with emphasis on the specifics of the high complexity of bio-systems. This introduction to molecular aspects of the field focuses on solvable models. Elementary biological processes provide as special challenge the presence of partial disorder in the structure which does not destroy the basic reproducibility of the processes. Apparently the elementary molecular processes are organized in a way to optimize the efficiency. Learning from nature by means exploring the relation between structure and function may even help to build better artificial solar cells.
The reader is exposed to basic concepts in modern biophysics, such as entropic forces, phase separation, potential of mean force, electron and proton transfer, heterogeneous reactions, coherent and incoherent energy transfer as well as molecular motors. Basic knowledge in classical and Quantum mechanics, electrostatics and statistical physics is desirable. Simplified models are presented which can be solved in limited cases analytically from the guiding lines to generate the basis for a fundamental understanding of the more complex biophysical systems. Chapters close with challenging problems whose solutions are provided at the end of the book to complete the pedagogical treatment in the book.
To the second edition several new chapters were added. The medium polarization is treated self-consistently using basic elements of polaron theory and more advanced nonlinear Schroedinger equations to describe the dynamics of solvation. Ion transport through a membrane was extended by the discussion of cooperative effects. Intramolecular transitions are now discussed in the new edition in much more detail, including also radiationless transitions. Very recent developments in spectroscopy are included, especially two-dimensional and hole-burning spectroscopy. The discussion of charge transfer processes was extended by including recent results of hole transfer in DNA in connection with the super-exchange mechanism. The chapter on molecular motors was rewritten to include the most recent developments of new models.
The book is a useful text for students and researchers wanting to go through the mathematical derivations in the theories presented. This book attracts a group of applied mathematically oriented students and scholars to the exciting field of molecular biophysics.
目次
Statistical Mechanics of Biopolymers.- Random Walk Models for the Conformation.- Flory-Huggins Theory for Biopolymer Solutions.- Protein Electrostatics and Solvation.- Implicit Continuum Solvent Models.- Debye-Huckel Theory.- Protonation Equilibria.- Reaction Kinetics.- Formal Kinetics.- Kinetic Theory: Fokker-Planck Equation.- Kramers' Theory.- Dispersive Kinetics.- Transport Processes.- Nonequilibrium Thermodynamics.- Simple Transport Processes.- Ion Transport Through a Membrane.- Reaction-Diffusion Systems.- Reaction Rate Theory.- Equilibrium Reactions.- Calculation of Reaction Rates.- Marcus Theory of Electron Transfer.- Elementry Photophysis.- Molecular States.- Optical Transitions.- The Displaced Harmonic Oscillator Model.- Spectral Diffusion.- Crossing of Two Electronic States.- Dynamics of an Excited State.- Elementry Photoinduced Processes.- Photophysics of Chlorophylls and Carotenoids.- Incoherent Energy Transfer.- Coherent Excitations in Photosynthetic Systems.- Ultrafast Electron Transfer Processes in the Photosynthetic Reaction Center.- Proton Transfer in Biomolecules.- Molecular Motor Models.- Continuous Ratchet Models.- Discrete Ratchet Models.- The Grand Canonical Ensemble.- Time Correlation Function of the Displaced Harmonic Oscillator Model.- The Saddle Point Method.
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