Biomolecular thermodynamics : from theory to application
著者
書誌事項
Biomolecular thermodynamics : from theory to application
（Foundations of biochemistry and biophysics series）
CRC Press, c2018
- : pbk
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
"an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus.... the ample problems and tutorials throughout are much appreciated."
-Tobin R. Sosnick, Professor and Chair of Biochemistry and Molecular Biology, University of Chicago
"Presents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels."
-Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University
"a masterful tour de force.... Barrick's rigor and scholarship come through in every chapter."
-Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis
This book provides a comprehensive, contemporary introduction to developing a quantitative understanding of how biological macromolecules behave using classical and statistical thermodynamics. The author focuses on practical skills needed to apply the underlying equations in real life examples. The text develops mechanistic models, showing how they connect to thermodynamic observables, presenting simulations of thermodynamic behavior, and analyzing experimental data. The reader is presented with plenty of exercises and problems to facilitate hands-on learning through mathematical simulation.
Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned his Ph.D. in biochemistry from Stanford University, and a Ph.D. in biophysics and structural biology from the University of Oregon.
目次
Series Preface
Preface
Acknowledgments
Note to Instructors
Author
Chapter 1 Probabilities and Statistics in Chemical and Biothermodynamics
Chapter 2 Mathematical Tools in Thermodynamics
Chapter 3 The Framework of Thermodynamics and the First Law
Chapter 4 The Second Law and Entropy
Chapter 5 Free Energy as a Potential for the Laboratory and for Biology
Chapter 6 Using Chemical Potentials to Describe Phase Transitions
Chapter 7 The Concentration Dependence of Chemical Potential, Mixing, and Reactions
Chapter 8 Conformational Equilibrium
Chapter 9 Statistical Thermodynamics and the Ensemble Method
Chapter 10 Ensembles That Interact with Their Surroundings
Chapter 11 Partition Functions for Single Molecules and Chemical Reactions
Chapter 12 The Helix-Coil Transition
Chapter 13 Ligand Binding Equilibria from a Macroscopic Perspective
Chapter 14 Ligand Binding Equilibria from a Microscopic Perspective
Appendix: How to Use Mathematica 485
Bibliography
Index
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