Chemical and biochemical approaches for the study of anesthetic function

著者

• Eckenhoff, Roderic G.
• Dmochowski, Ivan J.

書誌事項

Chemical and biochemical approaches for the study of anesthetic function

edited by Roderic G. Eckenhoff, Ivan J. Dmochowski

（Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan, v. 602-603）

Academic Press, Elsevier, 2018

1st ed

• pt. A
• pt. B

注記

Includes bibliographical references

内容説明・目次

巻冊次

pt. A ISBN 9780128127407

内容説明

Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data.

目次

Computational approaches 1. Physical accuracy leads to biological relevance: Best practices for simulating ligand-gated ion channels interacting with general anesthetics Grace Brannigan and Sruthi Murlidaran 2. Computational approaches for studying voltage-gated ion channels modulation by general anesthetics Vincenzo Carnevale 3. Anesthetic parameterization Jerome Henin 4. Pharmacophore QSAR, QM, ONIOM Edward Bertaccini 5. Kinetic modeling of electrophysiology data Robert Cantor Genetics and model organisms 6. General genetic strategies Philip G. Morgan 7. Worms Margaret Sedensky 8. Flies Bruno van Swinderen 9. Tadpoles Kellie Ann Woll 10. Zebrafish Victoria Bedell and Julia Dallman 11. Mice Max Kelz Photolabeling 12. Mass spect ID of adducts Kellie Ann Woll 13. Photolabeling protection/competition Jonathan Cohen Xenon 14. Xenon-protein interactions Benjamin Roose and Ivan Dmochowski 15. Xenon gas delivery/recovery procedures Mervyn Maze 16. Hyperpolarized Xe-129 MRI Mitchell Albert 17. CT imaging Andrew McKinstry-Wu Electrophysiology 18. Native system electrophysiology (slices, cells, in vivo) Boris Heifets 19. Voltage-gated ion channels (Kv, Nav) Manuel Covarrubias and Elaine Yang 20. Ligand-gated ion channels Stuart A. Forman

巻冊次

pt. B ISBN 9780128145746

内容説明

Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part B, Volume 603, presents a coherent description of the campaign towards understanding anesthesia. It includes a variety of highly debated topics, including sections on computational approaches, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, the kinetic modeling of electrophysiology data, evolving biophysical technologies, fluorescent anesthetics, lipids, membranes and pressure reversal, in vivo technologies, and more.

目次

• Computational approaches 1. Physical accuracy leads to biological relevance: Best practices for simulating ligand-gated ion channels interacting with general anesthetics 2. Computational approaches for studying voltage-gated ion channels modulation by general anesthetics 3. Anesthetic parameterization 4. Pharmacophore QSAR, QM, ONIOM 5. Kinetic modeling of electrophysiology data Genetics and model organisms 6. General genetic strategies 7. Worms 8. Flies 9. Tadpoles 10. Zebrafish 11. Mice Photolabeling 12. Mass spect ID of adducts 13. Photolabeling protection/competition Xenon 14. Xenon-protein interactions 15. Xenon gas delivery/recovery procedures 16. Hyperpolarized Xe-129 MRI 17. CT imaging Electrophysiology 18. Native system electrophysiology (slices, cells, in vivo) 19. Voltage-gated ion channels (Kv, Nav) 20. Ligand-gated ion channels 21. Other channels (HCN/K2P/TRP) Structural Approaches 22. Soluble proteins 23. Membrane proteins 24. NMR 25. Time-Resolved Neutron Interferometry and the Mechanism of Electromechanical Coupling in Voltage-Gated Ion Channels Evolving Biophysical Technologies 26. Fluorescent Anesthetics 27. Investigation of anesthetic-protein interactions by a thermodynamic approach 28. Tissue/organism EPR 29. Lipids, Membranes and Pressure reversal In vivo technologies
• established and evolving 30. Optoanesthesia 31. Optogenetics, Chemogenetics 32. Genetic reporters of neuronal activity: c-fos, genetically encoded calcium indicators 33. Genomics and Proteomic Techniques 34. Neurochemistry of Anesthetic States 35. Electroencephalography 36. PET 37. Drug discovery and development 38. The use of glutamatergic anesthetics (ketamine, nitrous oxide and xenon) in depression 39. Brain Imaging Using Hyperpolarized 129Xe MRI

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詳細情報

• NII書誌ID(NCID): BB25911869
• ISBN:
  • 9780128127407
  • 9780128145746
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Cambridge, Mass.
• ページ数/冊数: v.
• 大きさ: 24 cm
• 分類:
  • LCC : RD85.5
  • DC23 : 617.9/67
• 件名:
  • LCSH : Anesthetics -- Mechanism of action
  • LCSH : Anesthetics -- Physiological effect
• 親書誌ID:
  • BA00197543