Neuropsychiatric systemic lupus erythematosus : pathogenesis, clinical aspects and treatment
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書誌事項
Neuropsychiatric systemic lupus erythematosus : pathogenesis, clinical aspects and treatment
Springer, c2018
- : hbk.
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most recalcitrant complications of the disease. According to the 1999 ACR nomenclature and case definitions, diffuse psychiatric/neuropsychological syndromes in NPSLE (anxiety disorder, acute confusional state, cognitive dysfunction, mood disorder, psychosis) (diffuse NPSLE) present psychiatric manifestations unlike neurologic syndromes (focal NPSLE) originating from focal CNS lesions, such as cerebrovascular disease, demyelinating syndrome, headache, aseptic meningitis, chorea, seizures and myelopathy. A number of studies have reported that diffuse NPSLE is usually associated with the presence of autoantibodies against neuronal cells in serum as well as in cerebrospinal fluid (CSF). Moreover, IL-6 has been shown to be elevated in CSF of patients with diffuse NPSLE.
Recently, it has been demonstrated that the severity of blood-brain barrier damages plays a crucial role in the development of acute confusional state, the severest form of diffuse NPSLE through the accelerated entry of larger amounts of autoantibodies to NMDA receptor subunit NR2 into the CNS. Since the importance of autoantibodies in the NPSLE has been now evident, such an aggressive treatment, especially B cell depleting therapy, would make sense in that it would reduce the levels of pathogenic autoantibodies, leading to a better prognosis of NPSLE.
As far as we know, no single book specifically dedicated to NPSLE alone has been published as yet. As mentioned above, NPSLE constitutes a vastly expanding field of research with increasing numbers of papers published annually. Therefore, we believe that an effort to collect and critically review these publications is invaluable. Such an effort will provide an important contribution to basic researchers as well as clinicians working in the field of neurology, rheumatology, psychiatry and internal medicine fields.
目次
- Epidemiology
- Naoyuki Tsuchiya Genetics
- &nbs p
- Hiroshi Furukawa Immunology and pathogenesis
- Shunsei Hirohata Pathology
- Shunsei Hirohata, Masahisa Kyogoku Clinical Features
- Yoshiyuki Arinuma Cytokines Taku Yoshio Diagnosis and Differential diagnosis Taku Yoshio Imaging of NBD
- Tom W. Huizinga Psychiatic symptoms
- &nb sp
- Katsuji Nishimura Treatment
- John G. Hanly Promising treatment alternatives
- Dimitrious T. Boumpas Prognosis
- Shinsuke Yasuda
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