Muscarinic receptor : from structure to animal models
Author(s)
Bibliographic Information
Muscarinic receptor : from structure to animal models
（Neuromethods, 107）（Springer protocols）
Humana Press, 2016
- : hbk
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
This volume provides methods for characterization of muscarinic receptor in crystallography studies that advanced our understanding of structural properties and activation mechanism of muscarinic receptors and are cornerstone in molecular modeling and computer-based approaches to study muscarinic receptors. Muscarinic Receptor: From Structure to Animal Models guides readers through binding techniques, protocols to investigate molecular properties of muscarinic receptors, protocols to study muscarinic receptors in the central nervous system using autoradiography and PET studies and protocols on animals with knock-out and knock-in muscarinic genes to study role of muscarinic receptors in physiology and behavior. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.Concise and easy-to-use, Muscarinic Receptor: From Structure to Animal Models aims to ensure successful results in the further study of this vital field.
Table of Contents
1. Towards the Crystal Structure Determination of Muscarinic Acetylcholine Receptors
Ryoji Suno, Hidetsugu Asada, and Takuya Kobayashi
2. Homology Modeling and Docking Evaluation of Human Muscarinic Acetylcholine Receptors
Trayder Thomas, David K. Chalmers, and Elizabeth Yuriev
3. Radioligand Binding at Muscarinic Receptors
Esam E. El-Fakahany and Jan Jakubik
4. Binding Method for Detection of Muscarinic Acetylcholine Receptors in Receptor's Natural Environment
Ikunobu Muramatsu, Hatsumi Yoshiki, Kiyonao Sada, Junsuke Uwada, Takanobu Taniguchi, Takayoshi Masuoka, and Matomo Nishio
5. Use of Antibodies in the Research on Muscarinic Receptor Subtypes Wisuit Pradidarcheep and Martin C. Michel
6. Allosteric Modulation of Muscarinic Receptors
Jan Jakubik and Esam E. El-Fakahany
7. Subcellular and Synaptic Localization of Muscarinic Receptors in Neurons Using High-Resolution Electron Microscopic Preembedding Immunogold Technique
Veronique Bernard
8. Investigation of Muscarinic Receptors by Fluorescent Techniques
Cornelius Krasel, Andreas Rinne, and Moritz Bunemann
9. Autoradiography Assessment of Muscarinic Receptors in the Central Nervous System
Vladimir Farar and Jaromir Myslivecek
10. Imaging of Muscarinic Receptors in the Central Nervous System
Hideo Tsukada, Shingo Nishiyama, and Kazuhiro Takahashi
11. Detection of Non-Neuronal Acetylcholine
Ignaz Karl Wessler and Charles James Kirkpatrick
12. Utilization of Superfused Cerebral Slices in Probing Muscarinic Receptor Autoregulation of Acetylcholine Release
Vladimir Dolezal and Esam E. El-Fakahany
13. Regulation of Heart Contractility by M2 and M3 Muscarinic Receptors: Functional Studies using Muscarinic Receptor Knockout Mouse
Takio Kitazawa, Hiroki Teraoka, Nao Harada, Kenta Ochi, Tatsuro Nakamura, Koichi Asakawa, Shinya Kanegae, Noriko Yaosaka, Toshihiro Unno, Sei-ichi Komori, and Masahisa Yamada
14. Muscarinic Receptor Gene Transfections and In Vivo Dopamine Electrochemistry: Muscarinic Receptor Control of Dopamine-Dependent Reward and Locomotion
Stephan Steidl, David Ian Wasserman, Charles D. Blaha, and John Yeomans
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