Molecular mechanisms of notch signaling

著者

• Borggrefe, Tilman
• Giaimo, Benedetto Daniele

書誌事項

Molecular mechanisms of notch signaling

Tilman Borggrefe, Benedetto Daniele Giaimo, editors

（Advances in experimental medicine and biology, v. 1066）

Springer, c2018

注記

Includes bibliographical references and index

内容説明・目次

内容説明

This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.

目次

Preface Contributors Part 1 - Introduction 1. Introduction to Molecular Mechanisms in Notch Signal Transduction and Disease Pathogenesis Benedetto Daniele Giaimo and Tilman Borggrefe Part 2 - Molecular mechanisms of receptor/ligand interactions 2. Structural insights into Notch receptor-ligand interactions Penny Handford, Boguslawa Korona, Richard Suckling, Christina Redfield and Susan Lea 3. The Molecular Mechanism of Notch Activation Klaus N. Lovendahl, Stephen C. Blacklow and Wendy R. Gordon 4. Regulation of Notch Function by O-Glycosylation Beth M. Harvey and Robert S. Haltiwanger 5. Modeling the Notch response Udi Binshtok and David Sprinzak 6. Endocytic trafficking of the Notch receptor Bjoern Schnute, Tobias Troost and Thomas Klein Part 3 - Intracellular signaling mechanisms 7. The Notch Interactome: complexity in signaling circuitry Diana M. Ho, K. G. Guruharsha and Spyros Artavanis-Tsakonas 8. Integration of Drosophila and Human Genetics to understand Notch signaling related diseases Shinya Yamamoto and Jose L. Salazar 9. Mechanisms of non-canonical signaling in health and disease: Diversity to take therapy up a Notch? Victor Alfred and Thomas Vaccari 10. The Notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms Diana Bellavia, Saula Checquolo, Rocco Palermo and Isabella Screpanti 11. Notch and neurogenesis Anna Engler, Runrui Zhang and Verdon Taylor 12. Notch and stem cells Anna Bigas and Cristina Porcheri 13. Oscillatory control of Notch signaling in development Ryoichiro Kageyama, Hiromi Shimojo and Akihiro Isomura 14. CSL-associated corepressor and coactivator complexes Franz Oswald and Rhett A. Kovall Part 4 - Disease links and therapeutics 15. Notch and senescence Matthew Hoare and Masashi Narita 16. Control of blood vessel formation by Notch signaling Fabian Tetzlaff and Andreas Fischer 17. Notch and T cell function - a complex tale Jyothi Vijayaraghavan and Barbara A. Osborne 18. Notch in leukemia Anna C. Gormley, Qing Wang and Mark Chiangs

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詳細情報

• NII書誌ID(NCID): BB26659200
• ISBN:
  • 9783319895116
• LCCN: 2018949918
• 出版国コード: sz
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Cham
• ページ数/冊数: xxvii, 398 p.
• 大きさ: 27 cm
• 親書誌ID:
  • BA00008720