Developmental and reproductive toxicology
著者
書誌事項
Developmental and reproductive toxicology
（Methods in pharmacology and toxicology / Mannfred A. Hollinger, series editor）
Humana Press, c2017
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内容説明・目次
内容説明
This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab.
Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resource for researchers working in this vital field of study.
目次
1. Metabolism and Drug-Drug Interaction in Pregnant Mother/Placenta/Fetus
Ali S. Faqi and Karsten A. Holm
2. Critical Periods of Development in Teratology
Padmanahban Rengasamy
3. Nonclinical Safety Assessment of Developmental and Reproductive Toxicology: Considerations for Conducting Fertility, Embryo-Fetal Development, and Pre- and Postnatal Developmental Toxicology Studies
Kevin H. Denny and Ali S. Faqi
4. A Developmental and Reproductive Toxicology Program for Chemical Registration
Kamin J. Johnson, Bethany R. Hannas, Sue Marty, Carol L. Zablotny, Jessica LaRocca, Nicholas Ball, and Amanda
K. Andrus
5. The Influence of Environmental Contaminants and Lifestyle on Testicular Damage and Male Fertility
Sellappan Selvaraju, Meritxell Jodar, and Stephen A. Krawetz
6. Effects of Chemicals on Mammary Gland Development
Adam Filgo and Ali S. Faqi
7. Alternative Methods Used to Assess Potential Embryo-Fetal Developmental Risk of Pharmaceuticals
Maia L. Green, Joshua Gamse, and Kimberly C. Brannen
8. Using the Alternative Model C. elegans in Reproductive and Developmental Toxicology Studies
Daniel Ferreira, Yichang Chen, and Patrick Allard
9. High-Throughput Screens for Embryonic Stem Cells: Stress-Forced Potency-Stemness Loss Enables Toxicological Assays
Quanwen Li, Yu Yang, Erica Louden, Elizabeth E. Puscheck, and Daniel A. Rappolee
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