The hepatocyte review
著者
書誌事項
The hepatocyte review
Kluwer Academic Publishers, c2001
大学図書館所蔵 全1件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
"Softcover reprint of the hardcover 1st edition 2001"--T.p. verso
内容説明・目次
内容説明
It is thirty years since the technique of high-yield preparation of isolated hepatocytes, by collagenase perfusion of the liver, was published. The original method described by Berry and Friend has undergone many minor modifications by other workers, and the two-step procedure introduced by Seglen in 1976 has become the most frequent way to prepare hepatocyte suspensions. An important development introduced by Bissell in 1973 was the use of the cells as the first step in monolayer culture. The availability of the isolated hepatocyte preparation as cells in suspension or culture has undoubtedly facilitated research on the liver. This was emphasised in our book, published (with Dr. Greg Barritt) in 1990, which described in detail methods of preparation and the properties of the isolated hepatocytes. It also discussed the usefulness of the preparation for the study of intermediary and xenobiotic metabolism, calcium ion transport, and the growth and differentiation of hepatocytes in culture. The book also touched briefly on a range of specialised techniques, including peri fusion, subcellular fractionation, transplantation, cryopreservation and measurement of intracellular pH. Although standard procedures for the manipulation of hepatocytes have not changed a great deal in ten years, they have undoubtedly been refined. This applies particularly to hepatocyte culture techniques, cryopreservation, and even to preparation of hepatocyte suspensions, where it is now feasible to use purified enzymes. There is also much more emphasis on the use and study of human hepatocytes, particularly in the field of pharmacology and therapeutics.
目次
- Acknowledgements. Preface. Isolated hepatocytes: forty years on
- M.N. Berry. Isolation and culture of human hepatocytes
- M.J. Gomez-Lechon, J.V. Castell. Isolation and culture of porcine hepatocytes
- H.G. Koebe, et al. Preparation and properties of isolated hepatocytes from sheep
- M.G. Clark, M.A. Vincent. Elasmobranch hepatocytes
- N. Ballatori, et al. Isolation and cultivation of teleost hepatocytes
- T. Braunbeck, H. Segner. Conditions for growth of hepatocytes in culture
- A.M. Edwards, G. Michalopoulos. Engineering of a miniature 3-D hepatic cell plate culture model
- A. Bader, et al. Freezing and hypothermic storage of porcine hepatocytes
- H.G. Koebe, et al. Storage of isolated hepatocytes
- A. Guillouzo, et al. Hepatocyte swelling: techniques and effects on metabolism
- A.J. Meijer. Permeabilisation of hepatocytes with alpha-toxin
- P.E. Declercq, M.I. Baes. Perifused immobilised hepatocytes for metabolic studies
- H. Farghali. Small hepatocytes in primary cultures
- T. Mitaka, F. Sato. Mechanisms of hepatocyte growth regulation by hormones and growth factors
- T. Christoffersen, et al. Proliferative response and metabolic effects of growth factors in human hepatocytes
- M.J. Gomez-Lechon, et al. Growth control and cell cycle progression in cultured hepatocytes
- G. Ilyin, et al. Mechanisms of active cell death in isolated hepatocytes
- S. Maeda. The protective role of nitric oxide in hepatocytes during responses to inflammatory mediators and induction of apoptosis
- C.A. Bombeck, et al. Short-term regulation by insulin of glucose metabolism in isolated and cultured hepatocytes
- L. Agius, et al. Studies on mitochondrial-cytoplasmic interactions in isolated hepatocytes from fasted rats
- J.W. Phillips, etal. The importance of hepatocytes in drug metabolism studies: an industrial perspective
- M.K. Bayliss, D.M. Cross. Human hepatocytes as an experimental system for the evaluation of xenobiotics
- A.P. Li. Constitutive expression of cytochromes P450 in rat hepatocyte culture
- A.J. Paine. Optimising conditions for induction of cytochrome P450 in primary hepatocyte cultures
- G.M. Hawksworth, I. Stupans. The use of isolated hepatocytes to study the mechanisms of action of environmental contaminants
- S. Reader, F. Denizeau
- The use of isolated hepatocytes for the study of xenobiotic hepatotoxicity
- J. Wu, et al. Human hepatocyte transplantation: biology and therapy
- R.A. Fisher, S.C. Strom. Ex vivo hepatocyte-directed gene therapy
- S.E. Raper, A.D. Moscioni. A review of bioartificial liver development from an artificial organ engineering perspective
- M.D. Smith, et al. Development and testing of a bioartificial liver
- J. Rozga, A.A. Demetriou. The Berlin extracorporeal liver support system
- B. Busse, J. Gerlach. The bioartificial liver of the Academic Medical Center at Amsterdam
- R.A.F.M. Chamuleau, L.M. Flendrig. Performance of a flat membrane bioreactor utilizing porcine hepatocytes cultured in an extracellular matrix
- L. De Bartolo, A. Bader. Index.
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