A network-based approach to cell metabolism : from structure to flux balances
Author(s)
Bibliographic Information
A network-based approach to cell metabolism : from structure to flux balances
(Springer theses : recognizing outstanding Ph. D. research)
Springer, c2017
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  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
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  Chiba
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  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
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  Kyoto
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  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
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  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
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Note
"Doctoral thesis accepted by University of Barcelona, Barcelona, Spain"--T.p.
Includes bibliographical references
Description and Table of Contents
Description
This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures.
The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions.
Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec
ts of the networks themselves to the balance of biochemical fluxes.
Table of Contents
Cellular Metabolism at the Systems Level.- Methods and Data.- Structural Knockout Cascades in Metabolic Networks.- Effects of Reaction Knockouts on Steady States of Metabolism.- Detection of Evolution and Adaptation Fingerprints in Metabolic Networks.- Assessing FBA Optimal States in the Feasible Flux Phenotypic Space.- Conclusions.
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