The epigenetics of autoimmunity
著者
書誌事項
The epigenetics of autoimmunity
(Translational epigenetics series, v. 5)
Academic Press, an imprint of Elsevier, c2018
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high.
To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjoegren's syndrome (pSS) and autoimmune thyroid diseases (AITDs).
These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment.
目次
1. The epigenetics of autoimmunity: An overview 2. Immune cell development and epigenetics 3. DNA methylation and histone modifications in autoimmunity 4. MicroRNA and T helper cell-mediated immune responses 5. Long non-coding RNAs in the immune response 6. Epigenetics of Systemic Lupus Erythematosus 7. Rheumatoid Arthritis and Epigenetics 8. Epigenetic modifications in Multiple Sclerosis pathophysiology: potential diagnostic and therapeutic applications 9. Type 1 Diabetes and Epigenetics 10. Systemic Sclerosis and Epigenetics 11. Primary Sjoegren's Syndrome and Epigenetics 12. Autoimmune Thyroid Diseases and Epigenetics 13. The Epigenetics of Primary Biliary Cholangitis 14. Immune-mediated Pulmonary Disease and Epigenetics 15. The Epigenetics of Autoimmunity and Epigenetic Drug Discovery 16. Treatment of autoimmune diseases and prevention of transplant rejection/graft-versus-host disease by regulatory T cells: The state of the art and perspectives 17. Non-coding RNA-targeted therapeutics in autoimmune diseases: from bench to bedside 18. Future Challenges and Prospects for the epigenetics of autoimmunity
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