Glycobiophysics
著者
書誌事項
Glycobiophysics
(Advances in experimental medicine and biology, v. 1104)
Springer, c2018
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book presents state of the art biophysical approaches to issues in glycobiology that have cutting-edge applications. Despite the importance of glycosylation, the complexity, heterogeneity, and flexibility of the glycans have inhibited their study. Each chapter in this book explains very recent significant advances in biophysical approaches through the use of techniques such as NMR spectroscopy, mass spectrometry, single-molecule imaging, X-ray crystallography, high-speed atomic force microscopy, and computational simulation and their integrative application. Concrete examples are provided of the value of these techniques in addressing key problems in the field. In addition, significant functional glycobiological issues are considered. For example, glycolipids can form dynamic clusters on cell membranes and provide platforms for molecules involved in cell recognition and subsequent signal transduction. The detailed delineation of these molecular systems is discussed, revealing their structural complexity and ability to assemble transiently. This timely book will be of value for graduate students and postdocs interested in frontier topics in glycoscience and also for senior bio-researchers in academic and industrial fields.
目次
Preface.- Chapter 1: The effect of N-glycans on glycoprotein folding and protein dynamics.- Chapter 2: Synthesis of glycosylated metal complexes for probing carbohydrate-carbohydrate interactions.- Chapter 3: Unraveling of lipid raft organization in cell plasma membranes by single-molecule imaging of ganglioside probes.- Chapter 4: MALDI mass spectrometry imaging of N-linked glycans in tissues.- Chapter 5: Modern-omics technologies for isobaric glycan and glycoconjugate structure determination.- Chapter 6: Synchrotron-radiation vacuum-ultraviolet circular-dichroism spectroscopy for characterizing the structure of saccharides.- Chapter 7: Biophysical analyses for probing glycan-protein interactions.- Chapter 8: Structural aspects of ER glycoprotein quality-control system mediated by glucose tagging.- Chapter 9: Structural basis of protein Asn-glycosylation by oligosaccharyltransferases.- Chapter 10: Visualization of functional structure and kinetic dynamics of cellulases.- Chapter 11: Structure and dynamics of immunoglobulin G glycoproteins.- Chapter 12: Biophysical Approaches to Solve the Structures of the Complex Glycan Shield of Chloroviruses.- Chapter 13: Quantifying weak glycan-protein interactions using a Biolayer Interferometry competition assay: Applications to ECL lectin and X-31 influenza hemagglutinin.
「Nielsen BookData」 より