The Origin of a new progenitor stem cell group in human development : An immunohistochemical-, light- and electronmicroscopical Analysis
著者
書誌事項
The Origin of a new progenitor stem cell group in human development : An immunohistochemical-, light- and electronmicroscopical Analysis
(Advances in anatomy, embryology and cell biology, 230)
Springer, c2019
- : pbk
大学図書館所蔵 全1件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references
内容説明・目次
内容説明
This book presents an overview of a new group of progenitor stem cells. Their origins were originally detected in light- and electron microscopical sections of plastic embedded human embryonal and fetal organs.
The distribution of these cells can result in a large quantity of ectopic stem cells. The observation of these ectopic stem cells leads us to postulate the existence of a basic wave of stem cell progenitors. This process proceeds earlier and independently from germ cell migration. This first wave of progenitor stem cell migration initially reaches the peri-aortal AMG-region (Aortal-Mesonephric-Gonadal region). From here, some of these progenitor cells enter the aorta, are distributed through the vascular system and become the embryonal stem cells (reserve cells) in many peripheral tissues. A second part delivers progenitor cells for the adrenal 'anlage'. Within the peripheral Zona definitiva of the adrenal cortex the progenitor cells multiplicate and subsequently leave the adrenal cortex through a gate of the capsule. The progenitor cells arrive at the pre-aortal sympathic plexus ('second brain'). Within the plexus ganglia they form new organ-like clusters, the paraganglia. In a second process the progenitor cells (Chromaffine cells) enter sympathetic nerve bundles. Here an 'axonal migration' starts, which guides the progenitor cells to several peripheral organs. During this migration process the stem cells develop into their final state. In the adrenal cortex the ingrowing nerves guide the stem cells to the adrenal medulla. In the pancreas the ingrowing nerve fibers guide the stem cells to the islets.
These newly detected stem cells represent a specific developmental step which is found only in humans.
目次
Preface.- Chapter 1. Distribution of progenitor stem cells from the AMG-system an the adrenal.- Introduction.- Materials and Methods.- Chapter 1.1. The 'bidirectional' migration of human primordial germ cells (PGCs) including other stem cells.- Chapter 1.2. Distribution of fetal stem cells on the AMG-region, and how one group enters the human aorta and circulates in embryonal capillaries.- Chapter 1.3. Formation of the adrenal primordium in the AMG region and the development of the human adrenal cortex, notably the Zona definitiva.- Chapter 1.3.1 First stage of the adrenal gland development.- Chapter 1.3.2 Second period of the adrenal gland development.- Chapter 1.3.3 The third period of midgestational adrenal development.- Chapter 1.4. Further differentiation of the AMG-region: Development of the sympathetic cords, ganglia and paraganglia adjacent to the adrenal 'anlage': the 'second brain'.- Chapter 1.4.1 The Plexus coeliacus.- Chapter 1.4.2 The formation of paraganglia within the autonomic plexus.- Chapter 1.5. Discussion of the immigration of fetal stem cells into the autonomic NS, their role in the formation of the paraganglia and their axonal migration.- Chapter 2. Development of the adrenal medulla and other endocrine glands.- Chapter 2.1. Development of the autonomic innervation of the adrenal gland and the formation of the adrenal medulla.- Chapter 2.2. Development of the autonomic innervation of the human pancreas and origin of the pancreatic islets.- Chapter 2.3. Development of the human parathyroid gland.- Chapter 2.4. Fetal Stem Cells at perigonadal and intragonadal sites.- Chapter 2.5. Down-growth of autonomic nerves in the stomach and the intestine tube: the migration and the whereabouts of the stem cells.- Chapter 2.6. Discussion: the process of stem cell distribution and migration within the autonomic nerves to organs of the human developing organism.- Chapter 3. Final view on stem cell origin during human development.- Introduction.- Chapter 3.1. The origin of the stem cells of group II.- Chapter 3.2. Types of stem cells.- Chapter 3.2.1 Embryonic stem cells (eSCs).- Chapter 3.2.2 Naive stem cells and cells with primed pluripotent states.- Chapter 3.2.3 Neural crest stem cells (NCSCs).- Chapter 3.2.4 Induced stem cells (iSCs).- Chapter 3.2.5 Adult stem cells (adult SCs).- Chapter 3.3. Further stem cell categories during the human developmental process: the role of the AMG-region.- Chapter 3.4. How fetal stem cells deliver the progenitor cells of the adrenal cortex and how they pass into the local autonomic plexus.- Chapter 3.5. The cells multiplicated in the adrenal cortex become fetal stem cells.- Chapter 3.6. The role of the paraganglia during the stem cell storage and stem cell distribution.- Chapter 3.7. A new phylogenetical step during human development: the evolution of a new feedback system permitting a lifelong maintenance of stem cell supply. The paraganglia, autonomic nervous system, and 'axonal' stem cell migration system.- Chapter 3.8. Remaining questions and perspectives.- References.
「Nielsen BookData」 より