Nanomaterials in advanced medicine
著者
書誌事項
Nanomaterials in advanced medicine
Wiley-VCH, c2019
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
A comprehensive and multidisciplinary review of the fundamental concepts and medical applications of nanomaterials development technology
Nanomedicine offers a range of multi-interdisciplinary approaches and brings together the field of chemistry, pharmaceutical science, biology, and clinical medicines by focusing on design and preparation of biodegradable or non-biodegradable biomaterials for their biological, medical, and pharmaceutical applications. Nanomaterials in Advanced Medicine reviews the concepts and applications of the combination of the technology of biology and engineering that are emerging as an integral aspect of today?s advanced medicine. Nanomedicine provides the technology for imaging, cancer treatment, medical tools, bone treatment, drug delivery, diagnostic tests, drug development, angiogenesis and aims to exploit the improved and often novel physical, chemical, and biological properties of materials at the nanometer scale.
Designed to provide a broad survey of the field, Nanomaterials in Advanced Medicine is divided into three main sections: Nanophysics, Nanochemistry, and Nanomedicine. Each chapter describes in detail the most current and valuable methods available and contains numerous references to the primary literature. This important book:
-Offers a field guide for biologists and physicians who want to explore the fascinating world of nanotechnology
-Contains a comprehensive review of the topic from a noted expert in the field
-Includes an introduction to nanotechnology and explores the synthesis, structure and properties of various types of nanobiomaterials
-Bridges the gap between various aspects of nanomaterials? development technology and their applications
Written for pharmaceutical chemists, biotechnologists, life scientists, materials scientists, polymer chemists, and biochemists, Nanomaterials in Advanced Medicine provides a must-have guide to the fundamental concepts and current applications of nanomaterials in the medical field.
目次
Preface ix
1 Introduction to Nanotechnology 1
1.1 Introduction 1
1.2 Importance of Size in Nanotechnology 2
1.3 Approaches in Nanotechnology 2
1.3.1 Top-Down Approach 2
1.3.2 Bottom-Up Approach 3
1.4 Impact of Nanotechnology 4
1.4.1 Sensors for the Automotive Industry 4
1.4.2 Health and Medicine 5
1.4.3 Energy and Environment 5
1.4.4 National Security 5
1.5 Nanotechnology Applications 6
1.5.1 Information Technology 6
1.5.2 Energy 6
1.5.3 Medicine 6
1.5.4 Consumer Goods 6
1.6 Summary and Challenges 6
References 8
2 Biomaterials in Medicine 11
2.1 Introduction 11
2.2 Biodegradable Polymers 20
2.3 Natural Biomaterials 25
2.3.1 Gelatin 26
2.3.2 Pectin 27
2.3.3 Chitosan 28
2.3.4 Cyclodextrins (CDs) 29
2.3.5 Dextran, Dextran-Spermine (D-SPM) 30
2.3.6 Miscellaneous Polysaccharide Polymers 32
2.3.6.1 Pullulan 32
2.3.6.2 Schizophyllan 33
2.3.6.3 Alginic Acid 33
2.3.6.4 Hydroxypropyl Cellulose 33
2.3.6.5 Glycosaminoglycans 33
2.3.7 Modified Polysaccharides as Gene Delivering Agents 35
2.3.8 Cationic Lipid 38
2.4 Biodegradable Nanoparticles 39
References 40
3 Classification of Nanomaterials 47
3.1 Introduction 47
3.2 Classification of Nanomaterials 48
3.2.1 Nanoparticles 48
3.2.2 Nanofibers, Nanowires, and Nanorods 49
3.2.3 Self-assembly of Proteins and Peptides 52
3.3 Nanocarriers 54
3.3.1 Nanocarriers in Gene Therapy Technology 54
3.3.2 Nanocarriers in siRNA Technology 55
3.3.3 Colloidal Carrier System 57
3.3.4 Nanoparticulate System 59
3.4 Nanoscaffolding Materials 59
References 60
4 Nanomaterials in Gene Therapy Technology 63
4.1 Introduction 63
4.2 Approaches to Gene Therapy 64
4.2.1 Viral Vectors for Gene Delivery 64
4.2.2 Nonviral Vectors for Gene Delivery 65
4.2.2.1 Cationic Polymers 65
4.2.2.2 Cationic Lipid 72
4.2.2.3 Conventional Phosphate Method 72
4.2.2.4 Cell-Receptor-Mediated Uptake 72
4.3 Physical Methods for Gene Delivery 78
4.4 Combination of Physical and Nonviral Methods to Enhance DNA Nanoparticle Uptake by the Cells 80
4.5 Summary 91
References 92
5 Nanomaterials in Gene-Silencing Technology 109
5.1 Introduction 109
5.2 Gene Silencing 110
5.2.1 siRNAs 110
5.2.2 shRNAs 110
5.2.3 miRNAs 111
5.3 Approaches to siRNA Delivery Systems 111
5.4 siRNA Technology in Cancer Therapy 113
5.5 Future Prospects 114
References 114
6 Imaging Technology 117
6.1 Introduction 117
6.2 Polymeric Nanoparticles in MRI Technology and Disease Therapy 119
6.3 Surface-Coating Polymer in Nanoparticles 121
6.4 Drug Delivery with Polymeric Nanoparticles 122
6.5 Stimuli-Sensitive Drug Delivery 123
6.6 Multifunction of Targeted Drug Delivery 124
6.7 Gene Transfer via Polymeric Nanoparticles in Drug Delivery 124
6.8 Magnetic Hyperthermia 125
6.9 Future Prospects 126
References 126
7 Nanotechnology in Natural Hydrogel 133
7.1 Introduction 133
7.2 Mechanical Properties of Hydrogels and Interpenetrating Networks 134
7.3 Engineering Hydrogels with Controlled Mechanical, Chemical, and Biological Properties 138
7.4 Developing Methods of Fabricating Composite Biodegradable Hydrogels Using IPNs 139
7.5 Engineering Approaches to Deliver Growth Factors from Hydrogels 142
7.6 Drug Delivery Systems Using Polymeric Hydrogel 143
7.7 RNA-Responsive Hydrogels 146
7.8 DNA-Responsive Hydrogels 146
7.9 Aptamer-Responsive Hydrogels 147
References 148
8 Nanotechnology in Tissue Engineering 151
8.1 Introduction 151
8.2 3D In vitro Systems 153
8.2.1 Porous Scaffolds 153
8.2.2 Hydrogels 156
8.2.3 Self-assembly of Proteins 158
8.3 Cellular Microenvironment 160
8.3.1 Extracellular Matrix 160
8.3.2 Cellular Microenvironment (Niche) 160
8.3.3 Nerve Tissue 161
8.4 3D Technology on Frontier of Neuroscience 162
8.4.1 Tissue Engineering 162
8.4.2 Development of 3D In vitro Cell Culture Technology 164
8.4.3 Nerve Regeneration in 3D Models 164
8.4.4 Nanotechnology in Neuroscience 166
8.5 Regenerative Medicine Therapy 167
8.5.1 Specific Mediated Nanomaterials 167
8.5.1.1 Three-Dimensional Peptide Matrices 168
8.5.1.2 In vitro Biological Approaches of Self-Assembled Systems 169
8.5.1.3 Antimicrobial Activities 169
8.5.1.4 Cell Culture Scaffold for Tissue Engineering 170
8.5.1.5 Drug and Gene Delivery 171
8.5.2 Biomineralization Materials 174
8.5.3 Self-Assembled Systems in Regenerative Medicine Therapy 174
8.5.4 Enhancement of Angiogenesis in Self-Assembled Systems 175
8.5.5 Enhancement of Bone Regeneration in Self-Assembled Systems 178
8.5.6 Other Forms of Self-Assembled Systems in Regenerative Medicine 178
8.6 Future Prospects 179
References 180
9 Safety Issue of Nanomaterials 187
9.1 Introduction 187
9.2 Biocompatibility and Toxicity of Nanomaterials 188
9.2.1 In vitro Biological Approaches of Nanomaterials 188
9.2.2 Cell Cytotoxicity Assay 190
9.2.3 Chemical Reference Standard 190
9.3 Safety Issue of Nanomaterials 191
9.3.1 Quality Assurance Statement 191
9.3.2 Environmental, Health, and Safety Issues of Nanomaterials 192
9.3.3 Biohazard of Nanomaterials 193
9.4 Limitations of Nanomaterials Technology in Nature and Medicine 194
9.5 Future Prospects 195
References 196
Index 203
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