Adeno-associated virus vectors : Design and delivery
著者
書誌事項
Adeno-associated virus vectors : Design and delivery
（Methods in molecular biology / John M. Walker, series editor, 1950）（Springer protocols）
Humana Press, c2019
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This volume provides a complete and timely guide to the use of adeno-associated virus (AAV) vectors for genetic manipulation of mammalian tissues. Beginning with methods for the design and characterization of AAV vectors, the book continues with protocols for AAV delivery to various components of the central nervous system, to a number of sensory systems, and to a broad range of other tissues. Novel techniques such as ultrasound-targeted delivery to the brain, subpial delivery to the spinal cord, and subILM delivery to the retina are accompanied by chapters that provide an overview and comparison of current methods for AAV delivery to tissues such as brain, heart, liver, and lung. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible step-by-step laboratory protocols, and tips for troubleshooting and avoiding known pitfalls.
Authoritative and comprehensive, Adeno-Associated Virus Vectors: Design and Delivery aims to enhance the utility of AAV vectors for targeted gene transfer to living animals and continue the ongoing development of novel AAV-based gene therapies for human disease.
目次
Part I: Gene Delivery to the Central Nervous System
Chapter 1. Stereotactic Intraparenchymal Injection for Gene Delivery to the Brain
Chapter 2. MRI-Guided Intraparenchymal Injection for Gene Delivery to the Brain (Krystof Bankiewicz)
Chapter 3: Intravenous Infusion for Widespread Delivery to Nervous and Peripheral Tissues (Brian Kaspar)
Chapter 4: MRI-Guided Focused Ultrasound for Targeted Gene Delivery to the Brain (Isabelle Aubert)
Chapter 5: Intrathecal Infusion for Gene Delivery to the Nervous System (Mark Tuszynski and myself)
Chapter 6: Direct Intraparenchymal Injection for Gene Delivery to the Spinal Cord
Chapter 7: Retrograde Targeting of Spinal Motor Neurons by Muscle Injection
Chapter 8: Subpial Infusion for Widespread Gene Delivery to the Spinal Cord
Chapter 9: Intraganglionic Microinjection for Gene Delivery to the DRG
Chapter 10: Intravitreal Injection for Gene Delivery to the Eye
Chapter 11: Subretinal Injection for Gene Delivery to the Eye (Luk Vandenberghe)
[Chapters 10 and 11 could be combined into a single chapter for ocular delivery]
Part II: Gene Delivery to Peripheral Tissues
Chapter 12: Intranasal Administration for Gene Delivery to the Lung
Chapter 13: Orotracheal Administration for Gene Delivery to the Lung
Chapter 14: Surgical Tracheal Administration for Gene Delivery to the Lung
[Chapters 13 and 14 could be combined into a single chapter for tracheal delivery]
Chapter 15: Infusion of Coronary Artery for Global Gene Delivery to the Heart
Chapter 16: Aortic Occlusion and Pressurized Infusion for Global Gene Delivery to the Heart
[Chapters 15 and 16 could be combined into a single chapter for global heart delivery]
Chapter 17: Intramyocardial Injection for Targeted Gene Delivery to the Heart
Chapter 18: Intraportal Vein Injection for Global Gene Delivery to the Liver
Chapter 19: Intraparenchymal Injection for Targeted Gene Delivery to the Liver
Chapter 20: Gene Delivery to the Spleen
Chapter 21: Gene Delivery to the Kidney
Chapter 22: Gene Delivery to Skeletal Muscle
Part III: Design of Novel Vectors for Targeting of Specific Tissues and Cell Types
Chapter 23: Design of AAV vectors for Delivery of Large or Multiple Transgenes
Chapter 24: Design of AAV vectors for Delivery of RNAi
Chapter 25: Altering AAV tropism with Directed Evolution
Chapter 26: Altering AAV tropism with AAV-CREATE (Ben Deverman)
Chapter 27: Altering AAV tropism with Phage Display (Tomas Bjorklund)
Chapter 28: Minipromoters for Tissue- and Cell-Specific Gene Expression (Elizabeth Simpson)
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