Genetic epidemiology : methods and protocols
著者
書誌事項
Genetic epidemiology : methods and protocols
(Methods in molecular biology / John M. Walker, series editor, 1793)(Springer protocols)
Humana Press, c2018
大学図書館所蔵 全3件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.
目次
1. Introduction to Epidemiological Studies
Lazaros Belbasis and Vanesa Bellou
2. Key Concepts in Genetic Epidemiology
Kalliope Panoutsopoulou and Eleanor Wheeler
3. Quality Control of Common and Rare Variants
Kalliope Panoutsopoulou and Klaudia Walter
4. Genome Wide Association Studies
Abbas Dehghan
5. Assessing Rare Variation in Complex Traits
Karoline Kuchenbaecker and Emil Vincent Rosenbaum Appel
6. Meta-analysis of Common and Rare Variants
Kyriaki Michailidou
7. Gene-gene and Gene-environment Interactions
Andrew T. DeWan
8. Genetic Association in the HLA Region
Loukas Moutsianas and Javier Gutierrez-Achury
9. Novel Methods for Family-based Genetic Studies
Qi Yan
10. Methods for Polygenic Traits
Raha Pazoki
11. Multivariate Methods for Meta-analysis of Genetic Association Studies
Niki L. Dimou, Katerina G. Pantavou, Georgia G. Braliou, and Pantelis G. Bagos
12. Methods of Analysis and Meta-Analysis for Identifying Differentially Expressed Genes Panagiota I Kontou, Athanasia Pavlopoulou, and Pantelis G. Bagos
13. A Primer in Mendelian Randomization Methodology with a Focus on Utilizing Published Summary Association Data
Niki L. Dimou and Konstantinos K. Tsilidis
14. Copy Number Variation
Aurelien Mace, Zoltan Kutalik, and Armand Valsesia
15. From Identification to Function: Current Strategies to Prioritise and Follow-Up GWAS Results
Antonio J Berlanga-Taylor
16. Translating Human Genetics into Novel Drug Targets
Karol Estrada
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