Epigenetics of chronic pain
著者
書誌事項
Epigenetics of chronic pain
(Translational epigenetics series, v. 7)
Academic Press, an imprint of Elsevier, c2019
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
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  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies.
The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs.
目次
1. Epigenetic tools in chronic pain studies
2. Epigenetic regulation of peripheral macrophages in neuropathic pain
3. Emphasizing histone-related chromatin remodeling in the central nervous system of animal models of chronic pain
4. Role of histone modifications in chronic pain development
5. Role of DNA Methylation in Chronic Pain
6. Pain-induced chromatin modifications
7. DNA Methylation/Demethylation Homeostasis and Various Pain Conditions
8. Epigenetic Modulation of Visceral Pain
9. Non-coding RNAs are new players in chronic pain
10. Epigenetics of Chronic Visceral Nociception
11. An overview of epigenetic correlates of human chronic pain conditions
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