Industrial biotechnology : microorganisms

Author(s)

• Wittmann, Christoph
• Liao, James C.

Bibliographic Information

Industrial biotechnology : microorganisms

edited by Christoph Wittmann and James C. Liao

（Advanced biotechnology / series editors, S.Y. Lee, J. Nielsen, G. Stephanopoulos, v. 3a-3b）

Wiley-VCH, c2017

• v. 1
• v. 2

Note

Includes bibliographical references and index

Description and Table of Contents

Description

The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses.

Table of Contents

List of Contributors XVII About the Series Editors XXIX Preface XXXI Part I Industrial Biotechnology: From Pioneers to Visionary 1 1 History of Industrial Biotechnology 3 Arnold L. Demain, Erick J. Vandamme, John Collins, and Klaus Buchholz 1.1 The Beginning of Industrial Microbiology 3 1.2 Primary Metabolites and Enzymes 7 1.3 The Antibiotic Era 16 1.4 The Biotechnology Era Between 1970 and 2015 27 1.5 How Pioneering Developments Led to Genetic Engineering 48 References 73 2 Synthetic Biology: An Emerging Approach for Strain Engineering 85 Jie Sun and Hal Alper 2.1 Introduction 85 2.2 Basic Elements 86 2.3 Functional and Robust Modules 96 2.4 Microbial Communities 102 2.5 Conclusions and Future Prospects 104 Acknowledgments 104 References 104 3 Toward Genome-Scale Metabolic Pathway Analysis 111 Jurgen Zanghellini, Matthias P. Gerstl, Michael Hanscho, Govind Nair, Georg Regensburger, Stefan Muller, and Christian Jungreuthmayer 3.1 Introduction 111 3.2 DD Method 114 3.3 Calculating Short EFMs in Genome-Scale Metabolic Networks 116 3.4 Conclusions 120 Acknowledgments 121 References 121 4 Cell-Free Synthetic Systems for Metabolic Engineering and Biosynthetic Pathway Prototyping 125 Ashty S. Karim, Quentin M. Dudley, and Michael C. Jewett 4.1 Introduction 125 4.2 Background 127 4.3 The Benefits of Cell-Free Systems 129 4.4 Challenges and Opportunities in Cell-Free Systems 135 4.5 Recent Advances 140 4.6 Summary 141 Acknowledgments 141 References 142 Part II Multipurpose Bacterial Cell Factories 149 5 Industrial Biotechnology: Escherichia coli as a Host 151 Matthew Theisen and James C. Liao 5.1 Introduction 151 5.2 E. coli Products 152 5.3 Rewiring Central Metabolism 165 5.4 Alternative Carbon Sources 167 5.5 E. coli Techniques and Concerns 169 5.6 Conclusions 170 References 171 6 Industrial Microorganisms: Corynebacterium glutamicum 183 Judith Becker and Christoph Wittmann 6.1 Introduction 183 6.2 Physiology and Metabolism 185 6.3 Genetic Manipulation of Corynebacterium glutamicum 192 6.4 Systems Biology of Corynebacterium glutamicum 196 6.5 Application in Biotechnology 200 6.6 Conclusions and Perspectives 202 References 203 7 Host Organisms: Bacillus subtilis 221 Hans-Peter Hohmann, Jan M. van Dijl, Laxmi Krishnappa, and Zoltan Pragai 7.1 Introduction and Scope 221 7.2 Identification of Genetic Traits Pertinent to Enhanced Biosynthesis of a Value Product 222 7.3 Traits to Be Engineered for Enhanced Synthesis and Secretion of Proteinaceous Products 225 7.4 Engineering of Genetic Traits in Bacillus subtilis 231 7.5 Genome Reduction 245 7.6 Significance of Classical Strain Improvement in Times of Synthetic Biology 247 7.7 Resource-Efficient B. subtilis Fermentation Processes 252 7.8 Safety of Bacillus subtilis 254 7.9 Bacillus Production Strains on the Factory Floor: Some Examples 258 Acknowledgments 280 References 280 8 HostOrganism: Pseudomonas putida 299 Ignacio Poblete-Castro, Jose M. Borrero-de Acuna, Pablo I. Nikel, Michael Kohlstedt, and Christoph Wittmann 8.1 Introduction 299 8.2 Physiology and Metabolism 300 8.3 Genetic Manipulation 304 8.4 Systems Biology 307 8.5 Application in Biotechnology 311 8.6 Future Outlook 315 References 315 Part III Exploiting Anaerobic Biosynthetic Power 327 9 Host Organisms: Clostridium acetobutylicum/Clostridium beijerinckii and Related Organisms 329 Frank R. Bengelsdorf, Anja Poehlein, Stefanie K. Flitsch, Sonja Linder, Bettina Schiel-Bengelsdorf, Benjamin A. Stegmann, Preben Krabben, Edward Green, Ying Zhang, Nigel Minton, and Peter Durre 9.1 Introduction 329 9.2 Microorganisms 330 9.3 Bacteriophages 332 9.4 ABE Fermentation of Solvent-Producing Clostridium Strains 336 9.5 Genome-Based Comparison of Solvent-Producing Clostridium Strains 342 9.6 Regulation of Solvent Formation in C. acetobutylicum 345 9.7 Genetic Tools for Clostridial Species 346 9.8 Industrial Application of ABE Fermentation 353 Acknowledgments 355 References 355 10 Advances in Consolidated Bioprocessing Using Clostridium thermocellum and Thermoanaerobacter saccharolyticum 365 Lee R. Lynd, Adam M. Guss, Michael E. Himmel, Dhananjay Beri, Chris Herring, Evert K. Holwerda, Sean J. Murphy, Daniel G. Olson, Julie Paye, Thomas Rydzak, Xiongjun Shao, Liang Tian, and Robert Worthen 10.1 Introduction 365 10.2 CBP Organism Development Strategies 366 10.3 Plant Cell Wall Solubilization by C. thermocellum 367 10.4 Bioenergetics of C. thermocellum Cellulose Fermentation 372 10.5 Metabolic Engineering 378 10.6 Summary and Future Directions 386 Acknowledgments 388 References 388 11 Lactic Acid Bacteria 395 Luciana Ruiz-Rodriguez, Juliana Bleckwedel, Maria Eugenia Ortiz, Micaela Pescuma, and Fernanda Mozzi 11.1 Introduction 395 11.2 Fermented Foods 398 11.3 Industrially Relevant Compounds 406 11.4 Conclusions 434 Conflict of Interest 435 References 435 Contents to Volume 2 List of Contributors XV About the Series Editors XXVII Preface XXIX Part IV Microbial Treasure Chests for High-Value Natural Compounds 453 12 Host Organisms: Myxobacterium 455 Silke C. Wenzel and Rolf Muller 13 Host Organism: Streptomyces 487 Oksana Bilyk and Andriy Luzhetskyy Part V Extending the Raw Material Basis for Bioproduction 505 14 Extreme Thermophiles as Metabolic Engineering Platforms: Strategies and Current Perspective 507 Andrew J. Loder, Benjamin M. Zeldes, Jonathan M. Conway, James A. Counts, Christopher T. Straub, Piyum A. Khatibi, Laura L. Lee, Nicholas P. Vitko, Matthew W. Keller, Amanda M. Rhaesa, Gabe M. Rubinstein, Israel M. Scott, Gina L. Lipscomb, Michael W.W. Adams, and Robert M. Kelly 15 Cyanobacteria as a Host Organism 581 Fabienne Duchoud, Derrick S.W. Chuang, and James C. Liao 16 Host Organisms: Algae 605 Elizabeth A. Specht, Prema S. Karunanithi, Javier A. Gimpel, William S. Ansari, and Stephen P. Mayfield Part VI Eukaryotic Workhorses: Complex Cells Enable Complex Products 643 17 Host Organisms: Mammalian Cells 645 Jennifer Pfizenmaier and Ralf Takors 18 Industrial Microorganisms: Saccharomyces cerevisiae and other Yeasts 673 Diethard Mattanovich, Brigitte Gasser, Michael Egermeier, Hans Marx, and Michael Sauer 19 Industrial Microorganisms: Pichia pastoris 687 Diethard Mattanovich, Michael Sauer, and Brigitte Gasser Index 715

by "Nielsen BookData"

Details

• NCID: BB29568666
• ISBN:
  • 9783527341795
  • 9783527341795
• Country Code: gw
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Weinheim
• Pages/Volumes: 2 v. (xxxii, 724 p.)
• Size: 25 cm
• Classification:
  • DC23 : 660.62
• Subject Headings:
  • LCSH : Industrial microbiology
• Parent Bibliography ID:
  • BB2144253X