Biomarkers for preclinical Alzheimer's disease

著者

• Robert Perneczky

書誌事項

Biomarkers for preclinical Alzheimer's disease

edited by Robert Perneczky

（Neuromethods, 137）（Springer protocols）

Humana Press, c2018

• : pbk

注記

Includes bibliographical references and index

内容説明・目次

内容説明

This volume discusses the importance of imaging, fluid, and genetic biomarkers in detecting the earliest pre-symptomatic stages of Alzheimer's disease (AD). The chapters in this book are separated into five parts. Part one explores the reasons why we need improved approaches for early detection and diagnosis of AD. Part two describes clinical and research techniques for preclinical AD diagnosis. Part three looks at the current methods in use to diagnose AD and how they can also be used for early detection in healthy older individuals. Parts four and five talk about technological advancements in AD diagnosis and ethical considerations in AD research. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Biomarkers for Preclinical Alzheimer's Disease is a valuable resource for individuals interested in the use of biomarker strategies to improve early AD detection. This book will be of great interest to researchers and clinicians from both academia and industry."

目次

Series Preface... Preface... Table of Contents... Contributing Authors... Part I Alzheimer's Disease as a Societal Challenge 1. Worldwide Economic Costs and Societal Burden of Dementia Junfang Xu and Chengxuan Qiu 2. Epidemiology and Risk Factors of Alzheimer's Disease: A Focus on Diet Cecilia Samieri Part II Diagnostic Concepts 3. The Dimensional Structure of Subjective Cognitive Decline Miguel A. Fernandez-Blazquez, Marina Avila-Villanueva, and Miguel Medina 4. Deriving and Testing the Validity of Cognitive-Reserve Candidates Yaakov Stern and Christian Habeck 5. Methods for Pathological Classification of Alzheimer's Disease Johannes Attems, Kirsty E. McAleese, and Lauren Walker Part III Established Markers of Pathophysiology and Risk 6. Cerebrospinal Fluid Biomarkers of Preclinical Alzheimer's Disease Panagiotis Alexopoulos and Chaido Sirinian 7. Brain Structural Imaging in Alzheimer's Disease Sven Haller, Davide Zanchi, Cristelle Rodriguez, and Panteleimon Giannakopoulos 8. Brain Functional Imaging in Preclinical Alzheimer's Disease Peter Haussermann, Thorsten Bartsch, and Oliver Granert 9. Imaging of Brain Amyloid Load in Early Alzheimer's Disease Timo Grimmer and Jennifer Grace Perryman 10. Functional EEG Connectivity Alterations in Alzheimer's Disease Florian Hatz and Peter Fuhr Part IV Biomarker Discovery 11. A Selected Reaction Monitoring Protocol for the Measurement of sTREM2 in Cerebrospinal Fluid Amanda J. Heslegrave, Wendy E. Heywood, Kevin M. Mills, Henrik Zetterberg 12. Soluble Amyloid Precursor Proteins in Blood: Methods and Challenges Robert Perneczky and Panagiotis Alexopoulos 13. Tau Imaging in Preclinical Alzheimer's Disease Paul Edison 14. Retinal Imaging in Early Alzheimer's Disease Tom MacGillivray, Sarah McGrory, Tom Pearson, and James Cameron 15. In Vivo Volumetry of the Cholinergic Basal Forebrain Michel J. Grothe, Ingo Kilimann, Lea Grinberg, Helmut Heinsen, and Stefan Teipel Part V Patient Benefit and Ethical Considerations 16. Clinical Meaningfulness of Biomarkers Endpoints in Alzheimer's Disease Research Kok Pin Ng, Tharick A. Pascoal, Xiaofeng Li, Pedro Rosa-Neto, and Serge Gauthier 17. The Ethics of Biomarker-Based Preclinical Diagnosis of Alzheimer's Disease Alexander F. Kurz and Nicola T. Lautenschlager 18. Shared Decision-Making and Important Medical and Social Decisions in the Context of Early Diagnosis of Alzheimer's Disease Katharina Bronner and Johannes Hamann

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詳細情報

• NII書誌ID(NCID): BB29609989
• ISBN:
  • 9781493992553
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: New York
• ページ数/冊数: xiii, 272 p.
• 大きさ: 26 cm
• 親書誌ID:
  • BA07359406
  • BA88873632