Pharmacology of immunotherapeutic drugs
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書誌事項
Pharmacology of immunotherapeutic drugs
Springer, c2020
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs.
The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases.
The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are detailed. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named "Bench to Bedside." Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions.
The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.
目次
Chapter 1: Overview of the Immune System and its Pharmacological TargetsClinton B. Mathias, Ph.D.Figure Contributions: Jeremy P. McAleer, Ph.D.Table contributions by Doreen E. Szollosi, Ph.D. and Jeremy P. McAleer, Ph.D.
Chapter 2: Modulation of the Innate Immune SystemDoreen E. Szollosi, Ph.D.Clinton B. Mathias, Ph.D.
Chapter 3: Modulation of the Adaptive Immune SystemDoreen E. Szollosi, Ph.D.Clinton B. Mathias, Ph.D.Jeremy P. McAleer, Ph.D.From Bench to Bedside by Daniella D'Aquino
Chapter 4: Respiratory Disorders of the Immune System and their Pharmacological TreatmentClinton B. Mathias Ph.D.Figure Contributions: Jeffrey Rovatti, Pharm.D., Dylan Krajewski, Jeremy McAleer, Ph.D.Table Contributions: Kaitlin Armstrong, Kelsey Leite
Chapter 5: Inflammation of the Skin and its therapeutic targetsClinton B. Mathias, Ph.D.From Bench to Bedside by Kaitlin Armstrong
Chapter 6: Inflammatory Diseases of the Gastrointestinal Tract and Pharmacological TreatmentsClinton B. Mathias, Ph.D.Jeremy P. McAleer, Ph.D.Doreen E. Szollosi, Ph.D.Cases by Charles Babcock, Pharm.D., CDE, BCACP
Chapter 7: Mechanisms of Autoimmunity and Pharmacologic TreatmentsDoreen E. Szollosi, Ph.D.Kirsten Hokeness, Ph.D.Mohammed K. Manzoor, Pharm.D.Cases by Michele Riccardi, Pharm.D., BCPS
Chapter 8: Transplantation: Immunologic Principles and Pharmacologic AgentsClinton B. Mathias, Ph.D.Jeremy P. McAleer, Ph.D.From Bench to Bedside by Kaitlin Armstrong and Charles Babcock, Pharm.D., CDE, BCACPCase by Elizabeth Cohen, Pharm.D., BCPS
Chapter 9: Immunopathogenesis, Immunization, and Treatment of Infectious DiseasesDoreen E. Szollosi, Ph.D. Clinton B. Mathias, Ph.D.Victoria Lucero, Pharm.D.Sunna Ahmad, Pharm.D.Jennifer Donato, Pharm.D.Case by Andrea L. Leschak, Pharm.D., BCGP
Chapter 10: Cancer Immunotherapy Doreen E. Szollosi, Ph.D.Shannon R. M. Kinney, Ph.D.A.R.M. Ruhul Amin, Ph.D.Ngumbah Chumbow, Pharm.D.Figure contributions by Jeremy P. McAleer, Ph.D.From Bench to Bedside by Kaitlin Armstrong
Answer Key
Glossary of Abbreviations and Terms
Index
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