Osteosarcopenia : bone, muscle and fat interactions
著者
書誌事項
Osteosarcopenia : bone, muscle and fat interactions
Springer, c2019
大学図書館所蔵 全1件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes index
内容説明・目次
内容説明
This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies.
With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide.
Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions - including the role of local bone and muscle fat - followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons.
This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population.
The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.
目次
Dedication
Foreword - Cyrus Cooper
Preface - Gustavo Duque
Acknowledgements
PART I Biology of Muscle and Bone
1- Muscle and Bone Biology - Similarities and Differences
Joseph Elphingstone and Mark W. Hamrick
2- Mesenchymal stem cells as regulators of bone, muscle, and fat formation
Jeffrey M. Gimble
3- Age-related changes in muscle and bone
Julie A. Pasco
4- Cross-talk between muscle and bone
Chenglin Mo, Zhiying Wang, Leticia Brotto, Donnalee Pollack, Jian Huang, and Marco Brotto
5- Role of connexins and pannexins in bone and muscle mass and function
Lilian I. Plotkin and Hannah M. Davis
6- Osteosarcopenia as a Lipotoxic Disease
Ahmed Al Saedi, Craig Goodman, Damian Myers, Alan Hayes, and Gustavo Duque
7- The endocrine actions of undercarboxylated osteocalcin in skeletal muscle: effects and mechanisms
Xuzhu Lin, Alan Hayes, Glenn McConell, Gustavo Duque, Tara C. Brennan-Speranza, and Itamar Levinger
8- Sex steroid hormones and osteosarcopenia
Christian M. Girgis
9- Calciotropic hormones and osteosarcopenia
Guillaume T Duval, Helene Meytadier, Cedric Annweiler, and Gustavo Duque
10- Genetics of Osteosarcopenia
Katerina Trajanoska and Fernando Rivadeneira
PART II Clinical Characteristics
11- Diagnosis of Osteosarcopenia - clinical
Alberto Frisoli Junior
12- Diagnosis of Osteosarcopenia - Imaging
Adam J. Kuchnia and Neil Binkley
13- Diagnosis of osteosarcopenia - Biochemistry and pathology
Barbara Obermayer-Pietsch and Markus Herrmann
14- Osteosarcopenic obesity
David Scott
15- Non-pharmacological interventions for osteosarcopenia
Jacopo Antonino Vitale, Francesco Negrini, and Giuseppe Banfi
16- The Falls and Fractures Clinic - An integrated model of care for
osteosarcopenic patients
Fernando Gomez1 and Carmen-Lucia Curcio
Index
「Nielsen BookData」 より