Cyclic peptides : from bioorganic synthesis to applications
著者
書誌事項
Cyclic peptides : from bioorganic synthesis to applications
（Chemical biology, 6）
Royal Society of Chemistry, c2018
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注記
Includes bibliographical references and index
収録内容
- An introduction to cyclic peptides / Martin Empting
- The biosynthesis of cyclic peptides -RiPPs- an overview / Clarissa M. Czekster and James H. Naismith
- Thioesterase domain-mediated macrocyclization of non-ribosomal peptides / Sho Konno, Laëtitia Misson and Michael D. Burkart
- The biosynthetic machinery and its potential to deliver unnatural cyclic peptides / Rashed S. Al Toma, Natalia A. Jungmann and Roderich D. Süssmuth
- Modulation of protein-protein interactions using cyclic peptides / Salvador Guardiola, Sonia Ciudad, Laura Nevola and Ernest Giralt
- Biology and synthesis of the argyrins / L. Millbrodt and M. Kalesse
- Peptide cross-links catalyzed by metalloenzymes in natural product biosynthesis / Marcus I. Gibson, Clarissa C. Forneris and Mohammad R. Seyedsayamdost
- Double-click stapled peptides for inhibiting protein-protein interactions / K. Sharma, D.L. Kunciw, W. Xu, M.M. Wiedmann, Y. Wu, H.F. Sore, W.R.J.D. Galloway, Y.H. Lau, L.S. Itzhaki and D.R. Spring
- Libraries of head-to-tail peptides / Andrew T. Ball and Ali Tavassoli
- An introduction to bacterial lasso peptides / Julian D. Hegemann and Mohamed A. Marahiel
- Biological synthesis and affinity-based selection of small macrocyclic peptide ligands / Toby Passioura, Yuki Goto, Takayuki Katoh and Hiroaki Suga
- Mass spectrometric analysis of cyclic peptides / Yulin Qi and Dietrich A. Volmer
- Experimental and computational approaches to the study of macrocycle conformations in solution / Joshua Schwochert and R. Scott Lokey
- Trends in cyclotide research / Meng-Wei Kan and David J. Craik
- Cyclic peptides - a look to the future / Cristina N. Alexandru-Crivac, Luca Dalponte, Wael E. Houssen, Mohannad Idress, Marcel Jaspars, Kirstie A. Rickaby and Laurent Trembleau
内容説明・目次
内容説明
Cyclic peptides are increasingly employed as chemical tools in biology and drug discovery. They have gained a lot of interest as alternative sources of new drugs to traditional small molecules.
This book introduces cyclic peptides and provides a thorough overview of biosynthetic and fully synthetic approaches to their preparation. Following an introduction to cyclic peptides, biosynthetic and traditional chemical routes to cyclic peptides are reviewed. Due to their size, their synthesis is not trivial. Recent advances in the incorporation of novel structural units are presented in addition to how synthesis and biological methods can be combined. The chemical analysis of this molecular class is also discussed. Furthermore, chapters detail the progression of cyclic peptides as tools in biology and as potential drugs, providing a future vision of their importance.
In total, this book provides the reader with a comprehensive view of the state-of-the-art of cyclic peptides, from construction to possible clinical utility. This book will be an essential resource for students, researchers and scientists within industry in medicinal, bioorganic, natural product and analytical chemistry fields.
目次
- An Introduction to Cyclic Peptides
- The Biosynthesis of Cyclic Peptides – RiPPs – an Overview
- Thioesterase Domain-mediated Macrocyclization of Non-ribosomal Peptides
- The Biosynthetic Machinery and its Potential to Deliver Unnatural Cyclic Peptides
- Modulation of Protein–Protein Interactions Using Cyclic Peptides
- Biology and Synthesis of the Argyrins
- Peptide Cross-links Catalyzed by Metalloenzymes in Natural Product Biosynthesis
- Double-click Stapled Peptides for Inhibiting Protein–Protein Interactions
- Libraries of Head-to-Tail Peptides
- An Introduction to Bacterial Lasso Peptides
- Biological Synthesis and Affinity-Based Selection of Small Macrocyclic Peptide Ligands
- Mass Spectrometric Analysis of Cyclic Peptides
- Experimental and Computational Approaches to the Study of Macrocycle Conformations in Solution
- Trends in Cyclotide Research
- Cyclic Peptides – A Look to the Future
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