Pharmaceutical inhalation aerosol technology
Author(s)
Bibliographic Information
Pharmaceutical inhalation aerosol technology
(Drugs and the pharmaceutical sciences)
CRC Press, c2019
3rd ed
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Note
Includes bibliographies and index
Description and Table of Contents
Description
This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.
Key Features:
Provides a thoroughly revised and expanded reference with authoritative discussions on the physiologic,pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosols
Emphasizes the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery
Addresses the physics, chemistry and engineering principles while establishing disease relevance
Expands the 'technology' focus of the original volumes to address the title more directly
Offers an impressive breadth of coverage as well as an international flavour from outstanding editors and contributors
Table of Contents
Introduction
Discovery - pharmacology and physiology
Aerosol critical attributes - aerodynamic behavior, lung deposition and clearance
Active Pharmaceutical Ingredient/Drug Product manufacturing
Particle Engineering and Processing - milling, blending, spray drying, supercritical fluid, nano
Drug Product Formulation
Devices - design and performance
Drug Product Formulation
Product testing - physico-chemical properties, aerodynamic particle size, delivered dose
Regulatory considerations - CMC
Preclinical testing - dosing for cells and animals
Clinical testing - concepts of bioequivalence
General Conclusion
by "Nielsen BookData"