From structure to clinical development : allosteric modulation of G protein-coupled receptors

著者

    • Langmead, Christopher J.
    • Enna, S.J.
    • Lecount, Lynn

書誌事項

From structure to clinical development : allosteric modulation of G protein-coupled receptors

edited by Christopher J. Langmead

（Advances in pharmacology / edited by Silvio Garattini [and] Parkhurst A. Shore, v. 88）

Academic Press, 2020

  • hbk.

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注記

Serial editor: S.J. Enna

Managing editor: Lynn Lecount

内容説明・目次

内容説明

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo-switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP-1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure-based discovery and development of mGlu5 NAMs, and much more.

目次

The computational modeling of allosteric modulation of metabotropic glutamate receptors Laura Perez-Benito, Claudia Llinas del Torrent, Leonardo Pardo and Gary Tresadern Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators Kirstie A. Bennett, John A. Christopher and Benjamin G. Tehan The function and allosteric control of the human sweet taste receptor Guy Servant, Terry Kenakin, Lan Zhang, Mark Williams and Nicole Servant The different aspects of the GABAB receptor allosteric modulation Julie Kniazeff RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors Augen A. Pioszak and Debbie L. Hay Strategies and considerations of G-protein-coupled receptor photopharmacology Alice E. Berizzi and Cyril Goudet Discovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP. A novel tool to probe GLP-1R pharmacology Francis S. Willard, Joseph D. Ho and Kyle W. Sloop Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations Kari A. Johnson and David M. Lovinger Allosteric modulation of muscarinic receptors in alcohol and substance use disorders Leigh C. Walker and Andrew J. Lawrence M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease? Miriam Scarpa, Sarah Hesse and Sophie J. Bradley

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  • Advances in pharmacology

    edited by Silvio Garattini [and] Parkhurst A. Shore

    Academic Press 1962-

    Vol. 1 , Vol. 2 , Vol. 3 , Vol. 4 , Vol. 5 , Vol. 21 , Vol. 22 , Vol. 23 , Vol. 24 , Vol. 25 , Vol. 28 , Vol. 30 , Vol. 32 , Vol. 33 , Vol. 35 , Vol. 37 , Vol. 39 , Vol. 44 , Vol. 45 , Vol. 46

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