Animal models of diabetes : methods and protocols
Author(s)
Bibliographic Information
Animal models of diabetes : methods and protocols
（Methods in molecular biology / John M. Walker, series editor, 2128）（Springer protocols）
Humana Press, c2020
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
This volume discusses a variety of animal models of diabetes, as well as describes techniques used to study end-points when using these models. The chapters in this book cover topics such as important considerations when working with mouse models of diabetes, highlighting factors that new investigators may not be aware of and some potential pitfalls in experimental outcomes; main characteristics of some commonly used animal models of diabetes research, ranging from mice to primates; animal models used to study specific aspects of beta-cell biology; and a focus on techniques used to assess blood glucose homeostasis, insulin action, and islet function in vivo and ex vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and comprehensive, Animal Models of Diabetes: Methods and Protocols is a valuable resource that will help diabetes researchers design and carry out in vivo studies that will best suit their experimental questions and needs.
Table of Contents
Preface...Table of Contents...Contributing Authors...
1. Practical Considerations when Using Mouse Models of DiabetesAileen J.F. King, Lydia F. Daniels Gatward, and Matilda R. Kennard
2. An Overview of Rodent Models of Obesity and Type 2 DiabetesThomas A. Lutz
3. Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON MiceMototsugu Nagao, Jonathan Lou S. Esguerra, Anna Wendt, Akira Asai, Hitoshi Sugihara, Shinichi Oikawa, and Lena Eliasson
4. A Review of Mouse Models of Monogenic Diabetes and ER Stress SignallingParaskevi Salpea, Cristina Cosentino, and Mariana Igoillo-Esteve
5. Rat Models of Human Type 1 Diabetes Sigurd Lenzen, Tanja Arndt, Matthias Elsner, Dirk Wedekind, and Anne Joerns
6. Mouse Models of Autoimmune Diabetes: The Non-Obese Diabetic (NOD) Mouse Dawei Chen, Terri C. Thayer, Li Wen, and F. Susan Wong
7. Mouse Models of Virus-Induced Type 1 DiabetesGustaf Christoffersson and Malin Flodstroem-Tullberg
8. Rat Models of Virus-Induced Type 1 DiabetesJames C. Needell and Danny Zipris
9. Large Animal Models of DiabetesBarbara Ludwig, Eckhard Wolf, Uwe Schoenmann, and Stefan Ludwig
10. Use of Streptozotocin in Rodent Models of Islet Transplantation Aileen King, Elisabet Estil-les, and Eduard Montanya
11. Transplantation of Islets of Langerhans into the Anterior Chamber of the Eye for Longitudinal In Vivo Imaging Christian M. Cohrs, Chunguang Chen, and Stephan Speier
12. Multicolor Labeling and Tracing of Pancreatic Beta-Cell Proliferation in ZebrafishSumeet Pal Singh and Nikolay Ninoy
13. Generating Beta-Cell Specific Transgenic Mice Using the Cre-Lox SystemLorna I.F. Smith, Thomas G. Hill, and James E. Bowe
14. The Glucose Tolerance Test in MicePatricia Fonseca Pedro, Anastasia Tsakmaki, and Gavin A. Bewick
15. Assessment of Insulin Tolerance In Vivo in MiceIrene Cozar-Castellano and German Perdomo
16. Continuous Glucose Monitoring in Conscious Unrestrained MiceAileen J.F. King, Matilda R. Kennard, and Manasi Nandi
17. Assessing Mouse Islet FunctionPatricio Atanes, Inma Ruz-Maldonado, Oladapo E. Olaniru, and Shanta J. Persaud
18. Assessing Immune Responses in the Nonobese Diabetic Mouse Model of Type 1 DiabetesTerri C. Thayer, Dimitri Kakabadse, Joanne Boldison, and F. Susan Wong
19. Assessment of Insulin Tolerance Ex VivoIrene Cozar-Castellano and German Perdomo
20. Using Pancreas Tissue Slices for the Study of Islet PhysiologyJulia K. Panzer, Christian M. Cohrs, and Stephan Speier
21. Determining Beta Cell Mass, Apoptosis, Proliferation, and Individual Beta Cell Size in Pancreatic SectionsNoelia Tellez and Eduard Montanya
Subject Index List...
by "Nielsen BookData"
