Ion mobility-mass spectrometry : methods and protocols
著者
書誌事項
Ion mobility-mass spectrometry : methods and protocols
（Methods in molecular biology / John M. Walker, series editor, 2084）（Springer protocols）
Humana Press/Springer, c2020
- : hbk.
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収録内容
- Fundamentals of Ion Mobility-Mass Spectrometry for the Analysis of Biomolecules
- Utilizing Drift Tube Ion Mobility Spectrometry for the Evaluation of Metabolites and Xenobiotics
- Untargeted Differential Metabolomics Analysis Using Drift Tube Ion Mobility-Mass Spectrometry
- Drift Tube Ion Mobility-Mass Spectrometry for Non-Targeted 'Omics
- The Use of DMS-MS for the Quantitative Analysis of Acylcarnitines
- Traveling Wave Ion Mobility-Mass Spectrometry to Enhance the Detection of Low Abundance Features in Untargeted Lipidomics
- Lipidomics by HILIC-Ion Mobility-Mass Spectrometry
- A Workflow for the Identification of Mycotoxin Metabolites Using Liquid Chromatography?Ion Mobility-Mass Spectrometry
- Quantitation of Cyclosporin A in Cell Culture Media by Differential Mobility Mass Spectrometry (DMS-MS/MS)
- An Analytical Perspective on Protein Analysis and Discovery Proteomics by Ion Mobility-Mass Spectrometry
- Ion Mobility-Mass Spectrometry to Evaluate the Effects of Protein Modification or Small Molecule Binding on Protein Dynamics
- Liquid Extraction Surface Analysis (LESA) High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Mass Spectrometry for In Situ Analysis of Intact Proteins
- Ion Mobility-Mass Spectrometry of Glycoconjugates
- Desorption Atmospheric Pressure Photoionization Coupled with Ion Mobility-Mass Spectrometry
- Metabolomic Profiling of Adherent Mammalian Cells In Situ by LAESI-MS with Ion Mobility Separation
- Matrix-Assisted Laser Desorption and Desorption Electrospray Ionization Mass Spectrometry Coupled to Ion Mobility
- The Use of LipidIMMS Analyzer for Lipid Identification in Ion Mobility-Mass Spectrometry-Based Untargeted Lipidomics
- MolFind2: A Protocol for Acquiring and Integrating MS3 Data to Improve In-Silico Chemical Structure Elucidation for Metabolomics
- Collision Cross Section Calculations Using HPCCS
内容説明・目次
内容説明
This book focuses on ion mobility-mass spectrometry (IM-MS) and informatics approaches to improve traditional analysis of molecules by providing fundamentals and protocols for exploiting the potential of state-of-the-art IM-MS technology for the most common analytical applications. The chapters have been organized into four parts, each dealing with a particular set of IM-MS applications: 1) metabolomics and lipidomics; 2) proteomics and glycomics; 3) imaging and ambient ionization IM-MS; and 4) bioinformatic solutions for analyzing IM-MS data and deriving CCS values. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Ion Mobility-Mass Spectrometry: Methods and Protocols serves as an ideal resource for scientists delving into the technique's unprecedented analytical advantages, enabling novel qualitative and quantitative applications for the analysis of complex biological samples.
目次
1. Fundamentals of Ion Mobility-Mass Spectrometry for the Analysis of Biomolecules
Caleb B. Morris, James C. Poland, Jody C. May, and John A. McLean
Part I: Metabolomics and Lipidomics
2. Utilizing Drift Tube Ion Mobility Spectrometry for the Evaluation of Metabolites and Xenobiotics
Melanie T. Odenkirk and Erin S. Baker
3. Untargeted Differential Metabolomics Analysis Using Drift Tube Ion Mobility-Mass Spectrometry
Rick Reisdorph, Cole Michel, Kevin Quinn, Katrina Doenges, and Nichole Reisdorph
4. Drift Tube Ion Mobility-Mass Spectrometry for Non-Targeted 'Omics
Tim J. Causon, Ruwan T. Kurulugama, and Stephan Hann
5. The Use of DMS-MS for the Quantitative Analysis of Acylcarnitines
Nicholas B. Vera, Michelle Clasquin, Stephen L. Coy, and Paul Vouros
6. Traveling Wave Ion Mobility-Mass Spectrometry to Enhance the Detection of Low Abundance Features in Untargeted Lipidomics
Zeeshan Hamid and Andrea Armirotti
7. Lipidomics by HILIC-Ion Mobility-Mass Spectrometry
Amy Li, Kelly M. Hines, and Libin Xu
8. A Workflow for the Identification of Mycotoxin Metabolites Using Liquid Chromatography-Ion Mobility-Mass Spectrometry
Laura Righetti and Chiara Dall'Asta
9. Quantitation of Cyclosporin A in Cell Culture Media by Differential Mobility Mass Spectrometry (DMS-MS/MS)
Amol Kafle, James Glick, Stephen L. Coy, and Paul Vouros
Part II: Proteomics and Glycomics
10. An Analytical Perspective on Protein Analysis and Discovery Proteomics by Ion Mobility-Mass Spectrometry
Johannes P.C. Vissers and Michael McCullagh
11. Ion Mobility-Mass Spectrometry to Evaluate the Effects of Protein Modification or Small Molecule Binding on Protein Dynamics
Lauren J. Tomlinson and Claire E. Eyers
12. Liquid Extraction Surface Analysis (LESA) High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Mass Spectrometry for In Situ Analysis of Intact Proteins
Rian L. Griffiths, Klaudia I. Kocurek, and Helen J. Cooper
13. Ion Mobility-Mass Spectrometry of Glycoconjugates
Weston B. Struwe and David J. Harvey
Part III: Ambient Ionization and Imaging Ion Mobility Mass Spectrometry
14. Desorption Atmospheric Pressure Photoionization Coupled with Ion Mobility-Mass Spectrometry
Tiina J. Kauppila
15. Metabolomic Profiling of Adherent Mammalian Cells In Situ by LAESI-MS with Ion Mobility Separation
Sylwia A. Stopka and Akos Vertes
16. Matrix-Assisted Laser Desorption and Desorption Electrospray Ionization Mass Spectrometry Coupled to Ion Mobility
James I. Langridge and Emmanuelle Claude
Part IV: Bioinformatic Solutions for Analyzing IM-MS Data and Deriving CCS Values
17. The Use of LipidIMMS Analyzer for Lipid Identification in Ion Mobility-Mass Spectrometry-Based Untargeted Lipidomics
Xi Chen, Zhiwei Zhou, and Zheng-Jiang Zhu
18. MolFind2: A Protocol for Acquiring and Integrating MS3 Data to Improve In-Silico Chemical Structure Elucidation for Metabolomics
Milinda A. Samaraweera, Dennis W. Hill, and David F. Grant
19. Collision Cross Section Calculations Using HPCCS
Gabriel Heerdt, Leandro Zanotto, Paulo C.T. Souza, Guido Araujo, and Munir S. Skaf
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