Vaccination strategies against highly variable pathogens
著者
書誌事項
Vaccination strategies against highly variable pathogens
（Current topics in microbiology and immunology, 428）
Springer, c2020
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内容説明・目次
内容説明
Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits.
This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine.
目次
Successful Vaccines.- Immunogenicity and Immunodominance in Antibody Responses.- Immunogen Design.- Adjuvants.- Tools to screen vaccines.- Targeting glycans on human pathogens for vaccine design.- BnAbs and highly antigenically variable pathogens.
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