Metabolic and bioenergetic drivers of neurodegenerative disease : treating neurodegenerative diseases as metabolic diseases

著者

    • Söderbom, Grażyna

書誌事項

Metabolic and bioenergetic drivers of neurodegenerative disease : treating neurodegenerative diseases as metabolic diseases

edited by Grażyna Söderbom ... [et al.]

(International review of neurobiology / series editor, Patricia Janak, Peter Jenner, v. 155)

Academic Press, 2020

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注記

Includes bibliographical references

内容説明・目次

内容説明

Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer's and Parkinson's, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain - A Role in Type 2 Diabetes Mellitus and Alzheimer's disease; and much more.

目次

1. Dysregulation of metabolic flexibility: The impact of mTOR on autophagy in neurodegenerative diseases Kenneth Maiese 2. Antidiabetic drugs for Alzheimers and Parkinsons diseases: Repurposing insulin, metformin and thiazolidinediones Susana Cardoso and Paula I. Moreira 3. Evidence for pathophysiological commonalities between metabolic and neurodegenerative diseases Christian Hoelscher 4. Repurposing GLP1 agonists for neurodegenerative diseases Ioanna Markaki, Kristian Winther, Sergiu-Bogdan Catrina and Per Svenningsson 5. A role for Sodium Glucose coTransporter 2 inhibitors (SGLT2i) in the treatment of Alzheimer's disease? Russell Esterline, Jan Oscarsson and Jeffrey Burns 6. Ketotherapeutics for neurodegenerative diseases Nicholas G. Norwitz, Javier Gilbert Jaramillo, Kieran Clarke and Adrian Soto 7. Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases Yahyah Aman, Brent Ryan, Silje Boen Torsetnes, Anne-Brita Knapskog, Leiv Otto Watne, William A. McEwan and Evandro Fei Fang 8. Cellular senescence in aging and age-related disorders: Implications for neurodegenerative diseases Erin O. Wissler Gerdes, Yi Zhu, Bettina M. Weigand, Utkarsh Tripathi, Terence C. Burns, Tamar Tchkonia and James L. Kirkland 9. Harnessing neurogenesis in the adult brain-A role in type-2-diabetes mellitus and Alzheimer's disease Orly Lazarov, Richard D. Minshall and Marcelo G. Bonini 10. Hormesis: A therapeutic strategic approach in the treatment of neurodegenerative disease Edward J. Calabrese, Mark P. Mattson, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese and James Giordano

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