CiNii 図書 - The design & development of novel drugs and vaccines : principles and protocols

The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval.

1. Introduction of structural bioinformatics with respect to drug discovery 2. Target identification and validation 3. Retrieval of compounds 4. Lead identification and optimization 5. Molecular dynamics simulations 6. An overview of vaccine design 7. Key steps in the selection of vaccine targets 8. Epitope prediction and selection of linkers and adjuvant 9. Design of vaccine constructs 10. In-silico validation through protein-protein docking 11. Molecular cloning 12. Protein expression 13. Protein purification and desalting 14. Biological assay 15. Biophysical methods 16. Outline of animal study for lead/ vaccine testing 17. Evaluation of immunogenicity of vaccine candidate 18. In-vitro evaluation of lead molecule 19. Medical physiological parameter for lead/vaccine testing 20. Brief introduction of clinical research and trials 21. An overview of IND, NDA, approval agencies and FDA post-marketing surveillance 22. Introduction of Intellectual property rights

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The design & development of novel drugs and vaccines : principles and protocols

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