Personalized and precision medicine informatics : a workflow-based view
著者
書誌事項
Personalized and precision medicine informatics : a workflow-based view
（Health informatics）
Springer, c2020
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注記
Includes index
内容説明・目次
内容説明
This book adopts an integrated and workflow-based treatment of the field of personalized and precision medicine (PPM). Outlined within are established, proven and mature workflows as well as emerging and highly-promising opportunities for development. Each workflow is reviewed in terms of its operation and how they are enabled by a multitude of informatics methods and infrastructures. The book goes on to describe which parts are crucial to discovery and which are essential to delivery and how each of these interface and feed into one-another.
Personalized and Precision Medicine Informatics provides a comprehensive review of the integrative as well as interpretive nature of the topic and brings together a large body of literature to define the topic and ensure that this is the key reference for the topic. It is an unique contribution that is positioned to be an essential guide for both PPM experts and non-experts, and for both informatics and non-informatics professionals.
目次
Part I Introduction 1 Birth of a Discipline: Personalized and Precision Medicine (PPM) Informatics Part II Classical PPM 2 Clinical Risk Assessment and Prediction 3 Principles of Guideline-Driven Health Informatics 4 Genetic Counseling at the Intersection of Clinical Genetics and Informatics 5 Fundamentals of Drug Metabolism and Pharmacogenomics within a Learning Healthcare System Workflow Perspective 6 The Growing Medication Problem: Perspective from Industry Part III Emerging PPM 7 Risk Stratification and Prognosis Using Predictive Modelling and Big Data Approaches 8 Informatics Methods for Molecular Profiling 9 Constructing Software for Cancer Research in Support of Molecular PPM 10 Platform-Independent Gene-Expression Based Classification-System for Molecular Sub-Typing of Cancer 11 Tumor sequencing: Enabling Personalized Targeted Treatments with Informatics 12 Largescale Distributed PPM Databases: Harmonizing and Standardizing PPM Cohorts and Clinical Genomics Data Sharing Consortia 13 Redefining Disease Using Informatics 14 Pragmatic Trials and New Informatics Methods to Supplement or Replace Phase IV Trials 15 Precision Trials Informatics 16 Informatics for a Precision Learning Healthcare System Part IV Integrative Informatics for PPM 17 The Genomic Medical Record and Omic Ancillary Systems 18 Generalizable Architectures and Principles of Informatics for Scalable Personalized and Precision Medicine (PPM) Decision Support 19 Building Comprehensive Enterprise-Scale PPM Clinical Informatics Capability and Capacity 20 Personalized and Precision Medicine Informatics Education Part V Conclusion 21 The Landscape of PPM Informatics and the Future of Medicine
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