Genome editing : a practical guide to research and clinical applications

著者

• Musunuru, Kiran

書誌事項

Genome editing : a practical guide to research and clinical applications

Kiran Musunuru

Academic Press, an imprint of Elsevier, c2021

• : [pbk.]

注記

Includes bibliographical references and index

内容説明・目次

内容説明

Genome Editing: A Practical Guide to Research and Clinical Applications is geared towards investigators interested in learning how to use CRISPR-Cas9-based technologies, with a focus on cardiovascular research and clinical applications. Covering a range of topics from the basics of genome editing to design considerations, to assessments and applications, this reference allows readers to get started and establish a full workflow from the beginning of the project to its full completion. With worked examples drawn from real-life experiments, as well as troubleshooting and pitfalls to avoid, the book serves as an essential reference for researchers and investigators in both cardiovascular and biomedical research.

目次

1. Basic principles of genome editing2. Choosing a target site and editing strategy3. Choosing a nuclease, guide RNA, and repair template4. Assessing for off-target mutagenesis5. Assessing the outcomes of genome editing6. Base editing and other advanced forms of genome editing7. Epigenome editing8. Cellular disease modeling and risk prediction9. Functional experiments and screens10. Therapeutic applications11. Ethical implications

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BC09720834
• ISBN:
  • 9780128234846
• 出版国コード: uk
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: London
• ページ数/冊数: xii, 217 p.
• 大きさ: 24 cm
• 分類:
  • DC23 : 576.5072
• 件名:
  • LCSH : Gene editing
  • LCSH : CRISPR-associated protein 9
  • LCSH : CRISPR (Genetics)
  • LCSH : Cardiovascular system -- Diseases -- Genetic aspects