Handbook of nuclear medicine and molecular imaging for physicists
著者
書誌事項
Handbook of nuclear medicine and molecular imaging for physicists
（Series in medical physics and biomedical engineering）
CRC Press, 2022
- : set
- 3
- タイトル別名
-
Radiopharmaceuticals and clinical applications
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収録内容
- volume 3. Radiopharmaceuticals and clinical applications
内容説明・目次
- 巻冊次
-
3 ISBN 9781138593312
内容説明
This state-of-the-art handbook, the third and final in a series that provides medical physicists with a comprehensive overview into the field of nuclear medicine, focuses on highlighting the production and application of radiopharmaceuticals. With this, the book also describes the chemical composition of these compounds, as well as some of the main clinical applications where radiopharmaceuticals may be used.
Following an introduction to the field of radiopharmacy, three chapters in this book are dedicated towards in-depth descriptions of common radionuclides and radiopharmaceuticals used during diagnostic studies utilizing planar/Single Photon Emission Computed Tomography (SPECT) imaging, in addition to during Positron Emission Tomography (PET) imaging, and, finally, radiotherapy. These chapters are followed by those describing procedures relating to quality control and manufacturing (good manufacturing practices) also encompassing aspects such as environmental compliance. Furthermore, this volume illustrates how facilities handling these chemicals should be designed to comply with set regulations.
Like many pharmaceuticals, the development of radiopharmaceuticals relies heavily on the use of mouse models. Thus, the translation of radiopharmaceuticals (i.e., the process undertaken to assure that the functionality and safety of a newly developed drug is maintained also in a human context), is covered in a later chapter. This is followed by a chapter emphasising the importance of safe waste disposal and how to assure that these procedures meet the requirements set for the disposal of hazardous waste.
Several chapters have also been dedicated towards describing various medical procedures utilizing clinical nuclear medicine as a tool for diagnostics and therapeutics. As physicists may be involved in clinical trials, a chapter describing the procedures and regulations associated with these types of studies is included. This is followed by a chapter focusing on patient safety and another on an imaging modality not based on ionizing radiation - ultrasound. Finally, the last chapter of this book discusses future perspectives of the field of nuclear medicine.
This text will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine.
The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine
Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel
Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history
目次
Contents
Preface................................................................................................................................................................ix
Editor..................................................................................................................................................................xi
Contributors.................................................................................................................................................... xiii
Chapter 1 Principles behind Radiopharmacy.................................................................................................1
Thuy A. Tran and Erik Samen
Chapter 2 Radiopharmaceuticals for Diagnostics: Planar/ SPECT..............................................................13
Jim Ballinger and Jacek Koziorowski
Chapter 3 Radiopharmaceuticals for Diagnostics: PET...............................................................................27
Philip H. Elsinga
Chapter 4 Radiopharmaceuticals for Radionuclide Therapy.......................................................................39
Meltem Ocak, Emre Demirci, Jessie R. Nedrow and Rebecca Krimins
Chapter 5 Design Considerations for a Radiopharmaceutical Production Facility.....................................55
Nic Gillings
Chapter 6 Methods and Equipment for Quality Control of Radiopharmaceuticals.....................................59
Rolf Zijlma, Danique Giesen, Yvette Kruiter, Philip H. Elsinga and Gert Luurtsema
Chapter 7 Environmental Compliance and Control for Radiopharmaceutical Production: Commercial
Manufacturing and Extemporaneous Preparation......................................................................................71
Ching- Hung Chiu, Ya- Yao Huang, Wen- Yi Chang and Jacek Koziorowski
Chapter 8 GMP - Rules and Recommendations..........................................................................................87
Oliver Neels
Chapter 9 Management of Radioactive Waste in Nuclear Medicine...........................................................95
Lena Jonsson and Hanna Holstein
Chapter 10 Translation of Radiopharmaceuticals: Mouse to Man..............................................................101
Pedro Fragoso Costa, Latifa Rbah- Vidal, An Aerts, Fijs W.B. van Leeuwen and
Margret Schottelius
Chapter 11 Radionuclide Bone Scintigraphy...............................................................................................117
Kanhaiyalal Agrawal and Gopinath Gnanasegaran
vi
Chapter 12 Radionuclide Examination of the Kidneys................................................................................139
Martin Samal and Jiri Trnka
Chapter 13 Neuroimaging in Nuclear Medicine..........................................................................................173
Anne Larsson Stromvall and Susanna Jakobson Mo
Chapter 14 Methodology and Clinical Implementation of Ventilation/ Perfusion Tomography for Diagnosis
and Follow- up of Pulmonary Embolism and Other Pulmonary Diseases - Clinical Use of
Hybrid V/ P SPECT- CT.............................................................................................................189
Marika Bajc and Ari Lindqvist
Chapter 15 Myocardial Perfusion Imaging..................................................................................................201
Elin Tragardh, David Minarik and Mark Lubberink
Chapter 16 Infection and Inflammation.......................................................................................................213
Erik H.J.G. Aarntzen and Andor W.J.M. Glaudemans
Chapter 17 Special Considerations in Pediatric Nuclear Medicine.............................................................231
Sofie Lindskov Hansen, Soren Holm, Liselotte Hojgaard and Lise Borgwardt
Chapter 18 Antibody- based Radionuclide Imaging.....................................................................................243
Steffie M.B. Peters, Erik H.J.G. Aarntzen and Sandra Heskamp
Chapter 19 Radionuclide- based Diagnosis and Therapy of Prostate Cancer...............................................255
Sven- Erik Strand, Mohamed Altai, Joanna Strand and David Ulmert
Chapter 20 Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumours...................................305
Anna Sundlov and Katarina Sjogreen Gleisner
Chapter 21 Lymphoscintigraphy.................................................................................................................313
Rimma Axelsson, Maria Holstensson and Ulrika Estenberg
Chapter 22 Diagnostic Ultrasound..............................................................................................................325
Tomas Jansson
Chapter 23 Clinical Trials - Purpose and Procedures................................................................................337
Anna Sundlov
- 巻冊次
-
: set ISBN 9781138593350
内容説明
This state-of-the-art set of handbooks provides medical physicists with a comprehensive overview of the field of nuclear medicine. In addition to describing the underlying, fundamental theories of the field, it includes the latest research and explores the practical procedures, equipment, and regulations that are shaping the field and it's future. This set is split into three volumes, respectively titled: Instrumentation and Imaging Procedures; Modelling, Dosimetry and Radiation Protection; and Radiopharmaceuticals and Clinical Applications.
Volume one, Instrumentation and Imaging Procedures, focuses primarily on providing a comprehensive review into the detection of radiation, beginning with an introduction to the history of nuclear medicine to the latest imaging technology. Volume two, Modelling, Dosimetry and Radiation Protection, explores the applications of mathematical modelling, dosimetry, and radiation protection in nuclear medicine. The third and final volume, Radiopharmaceuticals and Clinical Applications, highlights the production and application of radiopharmaceuticals and their role in clinical nuclear medicine practice.
These books will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine.
The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine
Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel
Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history
目次
Volume I: Instrumentation and Images Processing.
1. The History of Nuclear Medicine
2. Basics of Nuclear Physics
3. Basics of Radiation Interaction in Matter
4. Radionuclide Production
5. Radiometry
6. Scintillation Detectors
7. Semiconductor Detectors
8. Gamma Spectroscopy
9. Properties of the Digital Image
10. Digital Image Processing
11. Machine-Learning
12. Image File Structures in Nuclear Medicine
13. The Scintillation Camera
14. Collimators for Gamma Ray Imaging
15. Image Acquisition Protocols
16. Single Photon Emission Computed Tomography (SPECT) and SPECT/CT Hybrid Imaging
17. Dedicated Tomographic Single Photon Systems
18. Positron Emission Tomography (PET)
19. Dead Time Effects in Nuclear Medicine Imaging Studies
20. Principles of Iterative Reconstruction for Emission Tomography
21. Clinical Molecular PET/CT Hybrid Imaging
22. Clinical Molecular PET/MRI Hybrid Imaging
23. Quality Assurance of Nuclear Medicine Systems
24. Calibration and Traceability
25. Activity Quantification from Planar images
26. Quantitation in Emission Tomography
27. Multicenter studies: Hardware and Software Requirements
28. Pre-Clinical Molecular Imaging Systems
29. Monte Carlo simulations of Nuclear Medicine Imaging Systems
30. Beta and Alpha Particle Autoradiography
31. Principles behind Computed Tomography (CT)
32. Principles behind Magnetic Resonance Imaging (MRI)
Volume II: Dosimetry and Radiation Protection .
1. Introduction to Biostatistics
2. Radiobiology
3. Diagnostic Dosimetry
4. Time-Activity Curves: Data, Models, Curve Fitting and Model Selection
5. Tracer Kinetic Modelling and its use in PET Quantification
6. Principles of Radiological Protection in Healthcare
7. Controversies in Nuclear Medicine Dosimetry
8. Monte Carlo Simulation of Photon and Electron Transport in Matter
9. Patient Models for Dosimetry Applications
10. Patient-Specific Dosimetry Calculations
11. Whole Body Dosimetry
12. Personalized Dosimetry in Radioembolization
13. Thyroid Imaging and Dosimetry
14. Bone Marrow Dosimetry
15. Cellular and Multicellular Dosimetry
16. Alpha-Particle Dosimetry
17. Staff Radiation Protection
18. IAEA support to Nuclear Medicine
Volume III: Radiopharmaceuticals and Clinical Applications.
1. Principles behind Radiopharmacy
2. Radiopharmaceuticals for diagnostics: Planar/SPECT
3. Radiopharmaceuticals for diagnostics: PET
4. Radiopharmaceuticals for radionuclide therapy
5. Design Considerations for a Radiopharmaceutical Production Facility
6. Methods and Equipment for Quality Control of Radiopharmaceuticals
7. Environmental Compliance and Control for Radiopharmaceutical Production: Commercial Manufacturing and Extemporaneous Preparation
8. GMP - rules and recommendations
9. Management of Radioactive Waste in Nuclear Medicine
10. Translation of Radiopharmaceuticals: Mouse to Man
11. Radionuclide Bone Scintigraphy
12. Radionuclide Examinations of the Kidneys
13. Neuroimaging in Nuclear Medicine
14. Methodology and Clinical Implementation of Ventilation/Perfusion Tomography for Diagnosis and Follow-up of Pulmonary Embolism and Other Pulmonary Diseases Clinical use of hybrid V/P SPECT-CT
15. Myocardiac Perfusion Imaging
16. Infection and Inflammation
17. Special Considerations In Pediatric Nuclear Medicine
19. Antibody-Based Radionuclide Imaging
18. Radionuclide-Based Diagnosis and Therapy of Prostate Cancer
20. Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors
21. Lymphoscintigraphy
22. Diagnostic Ultrasound
Tomas Jansson
23. Clinical Trials - Purpose and Procedures
24. Introduction to Patient Safety and Improvement Knowledge
25. Closing remarks
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