CiNii 図書 - Handbook of nuclear medicine and molecular imaging for physicists

This state-of-the-art handbook, the third and final in a series that provides medical physicists with a comprehensive overview into the field of nuclear medicine, focuses on highlighting the production and application of radiopharmaceuticals. With this, the book also describes the chemical composition of these compounds, as well as some of the main clinical applications where radiopharmaceuticals may be used. Following an introduction to the field of radiopharmacy, three chapters in this book are dedicated towards in-depth descriptions of common radionuclides and radiopharmaceuticals used during diagnostic studies utilizing planar/Single Photon Emission Computed Tomography (SPECT) imaging, in addition to during Positron Emission Tomography (PET) imaging, and, finally, radiotherapy. These chapters are followed by those describing procedures relating to quality control and manufacturing (good manufacturing practices) also encompassing aspects such as environmental compliance. Furthermore, this volume illustrates how facilities handling these chemicals should be designed to comply with set regulations. Like many pharmaceuticals, the development of radiopharmaceuticals relies heavily on the use of mouse models. Thus, the translation of radiopharmaceuticals (i.e., the process undertaken to assure that the functionality and safety of a newly developed drug is maintained also in a human context), is covered in a later chapter. This is followed by a chapter emphasising the importance of safe waste disposal and how to assure that these procedures meet the requirements set for the disposal of hazardous waste. Several chapters have also been dedicated towards describing various medical procedures utilizing clinical nuclear medicine as a tool for diagnostics and therapeutics. As physicists may be involved in clinical trials, a chapter describing the procedures and regulations associated with these types of studies is included. This is followed by a chapter focusing on patient safety and another on an imaging modality not based on ionizing radiation - ultrasound. Finally, the last chapter of this book discusses future perspectives of the field of nuclear medicine. This text will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine. The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history

Contents Preface................................................................................................................................................................ix Editor..................................................................................................................................................................xi Contributors.................................................................................................................................................... xiii Chapter 1 Principles behind Radiopharmacy.................................................................................................1 Thuy A. Tran and Erik Samen Chapter 2 Radiopharmaceuticals for Diagnostics: Planar/ SPECT..............................................................13 Jim Ballinger and Jacek Koziorowski Chapter 3 Radiopharmaceuticals for Diagnostics: PET...............................................................................27 Philip H. Elsinga Chapter 4 Radiopharmaceuticals for Radionuclide Therapy.......................................................................39 Meltem Ocak, Emre Demirci, Jessie R. Nedrow and Rebecca Krimins Chapter 5 Design Considerations for a Radiopharmaceutical Production Facility.....................................55 Nic Gillings Chapter 6 Methods and Equipment for Quality Control of Radiopharmaceuticals.....................................59 Rolf Zijlma, Danique Giesen, Yvette Kruiter, Philip H. Elsinga and Gert Luurtsema Chapter 7 Environmental Compliance and Control for Radiopharmaceutical Production: Commercial Manufacturing and Extemporaneous Preparation......................................................................................71 Ching- Hung Chiu, Ya- Yao Huang, Wen- Yi Chang and Jacek Koziorowski Chapter 8 GMP - Rules and Recommendations..........................................................................................87 Oliver Neels Chapter 9 Management of Radioactive Waste in Nuclear Medicine...........................................................95 Lena Jonsson and Hanna Holstein Chapter 10 Translation of Radiopharmaceuticals: Mouse to Man..............................................................101 Pedro Fragoso Costa, Latifa Rbah- Vidal, An Aerts, Fijs W.B. van Leeuwen and Margret Schottelius Chapter 11 Radionuclide Bone Scintigraphy...............................................................................................117 Kanhaiyalal Agrawal and Gopinath Gnanasegaran vi Chapter 12 Radionuclide Examination of the Kidneys................................................................................139 Martin Samal and Jiri Trnka Chapter 13 Neuroimaging in Nuclear Medicine..........................................................................................173 Anne Larsson Stromvall and Susanna Jakobson Mo Chapter 14 Methodology and Clinical Implementation of Ventilation/ Perfusion Tomography for Diagnosis and Follow- up of Pulmonary Embolism and Other Pulmonary Diseases - Clinical Use of Hybrid V/ P SPECT- CT.............................................................................................................189 Marika Bajc and Ari Lindqvist Chapter 15 Myocardial Perfusion Imaging..................................................................................................201 Elin Tragardh, David Minarik and Mark Lubberink Chapter 16 Infection and Inflammation.......................................................................................................213 Erik H.J.G. Aarntzen and Andor W.J.M. Glaudemans Chapter 17 Special Considerations in Pediatric Nuclear Medicine.............................................................231 Sofie Lindskov Hansen, Soren Holm, Liselotte Hojgaard and Lise Borgwardt Chapter 18 Antibody- based Radionuclide Imaging.....................................................................................243 Steffie M.B. Peters, Erik H.J.G. Aarntzen and Sandra Heskamp Chapter 19 Radionuclide- based Diagnosis and Therapy of Prostate Cancer...............................................255 Sven- Erik Strand, Mohamed Altai, Joanna Strand and David Ulmert Chapter 20 Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumours...................................305 Anna Sundlov and Katarina Sjogreen Gleisner Chapter 21 Lymphoscintigraphy.................................................................................................................313 Rimma Axelsson, Maria Holstensson and Ulrika Estenberg Chapter 22 Diagnostic Ultrasound..............................................................................................................325 Tomas Jansson Chapter 23 Clinical Trials - Purpose and Procedures................................................................................337 Anna Sundlov

巻冊次: : set ISBN 9781138593350

内容説明

This state-of-the-art set of handbooks provides medical physicists with a comprehensive overview of the field of nuclear medicine. In addition to describing the underlying, fundamental theories of the field, it includes the latest research and explores the practical procedures, equipment, and regulations that are shaping the field and it's future. This set is split into three volumes, respectively titled: Instrumentation and Imaging Procedures; Modelling, Dosimetry and Radiation Protection; and Radiopharmaceuticals and Clinical Applications. Volume one, Instrumentation and Imaging Procedures, focuses primarily on providing a comprehensive review into the detection of radiation, beginning with an introduction to the history of nuclear medicine to the latest imaging technology. Volume two, Modelling, Dosimetry and Radiation Protection, explores the applications of mathematical modelling, dosimetry, and radiation protection in nuclear medicine. The third and final volume, Radiopharmaceuticals and Clinical Applications, highlights the production and application of radiopharmaceuticals and their role in clinical nuclear medicine practice. These books will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine. The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history

Volume I: Instrumentation and Images Processing. 1. The History of Nuclear Medicine 2. Basics of Nuclear Physics 3. Basics of Radiation Interaction in Matter 4. Radionuclide Production 5. Radiometry 6. Scintillation Detectors 7. Semiconductor Detectors 8. Gamma Spectroscopy 9. Properties of the Digital Image 10. Digital Image Processing 11. Machine-Learning 12. Image File Structures in Nuclear Medicine 13. The Scintillation Camera 14. Collimators for Gamma Ray Imaging 15. Image Acquisition Protocols 16. Single Photon Emission Computed Tomography (SPECT) and SPECT/CT Hybrid Imaging 17. Dedicated Tomographic Single Photon Systems 18. Positron Emission Tomography (PET) 19. Dead Time Effects in Nuclear Medicine Imaging Studies 20. Principles of Iterative Reconstruction for Emission Tomography 21. Clinical Molecular PET/CT Hybrid Imaging 22. Clinical Molecular PET/MRI Hybrid Imaging 23. Quality Assurance of Nuclear Medicine Systems 24. Calibration and Traceability 25. Activity Quantification from Planar images 26. Quantitation in Emission Tomography 27. Multicenter studies: Hardware and Software Requirements 28. Pre-Clinical Molecular Imaging Systems 29. Monte Carlo simulations of Nuclear Medicine Imaging Systems 30. Beta and Alpha Particle Autoradiography 31. Principles behind Computed Tomography (CT) 32. Principles behind Magnetic Resonance Imaging (MRI) Volume II: Dosimetry and Radiation Protection . 1. Introduction to Biostatistics 2. Radiobiology 3. Diagnostic Dosimetry 4. Time-Activity Curves: Data, Models, Curve Fitting and Model Selection 5. Tracer Kinetic Modelling and its use in PET Quantification 6. Principles of Radiological Protection in Healthcare 7. Controversies in Nuclear Medicine Dosimetry 8. Monte Carlo Simulation of Photon and Electron Transport in Matter 9. Patient Models for Dosimetry Applications 10. Patient-Specific Dosimetry Calculations 11. Whole Body Dosimetry 12. Personalized Dosimetry in Radioembolization 13. Thyroid Imaging and Dosimetry 14. Bone Marrow Dosimetry 15. Cellular and Multicellular Dosimetry 16. Alpha-Particle Dosimetry 17. Staff Radiation Protection 18. IAEA support to Nuclear Medicine Volume III: Radiopharmaceuticals and Clinical Applications. 1. Principles behind Radiopharmacy 2. Radiopharmaceuticals for diagnostics: Planar/SPECT 3. Radiopharmaceuticals for diagnostics: PET 4. Radiopharmaceuticals for radionuclide therapy 5. Design Considerations for a Radiopharmaceutical Production Facility 6. Methods and Equipment for Quality Control of Radiopharmaceuticals 7. Environmental Compliance and Control for Radiopharmaceutical Production: Commercial Manufacturing and Extemporaneous Preparation 8. GMP - rules and recommendations 9. Management of Radioactive Waste in Nuclear Medicine 10. Translation of Radiopharmaceuticals: Mouse to Man 11. Radionuclide Bone Scintigraphy 12. Radionuclide Examinations of the Kidneys 13. Neuroimaging in Nuclear Medicine 14. Methodology and Clinical Implementation of Ventilation/Perfusion Tomography for Diagnosis and Follow-up of Pulmonary Embolism and Other Pulmonary Diseases Clinical use of hybrid V/P SPECT-CT 15. Myocardiac Perfusion Imaging 16. Infection and Inflammation 17. Special Considerations In Pediatric Nuclear Medicine 19. Antibody-Based Radionuclide Imaging 18. Radionuclide-Based Diagnosis and Therapy of Prostate Cancer 20. Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors 21. Lymphoscintigraphy 22. Diagnostic Ultrasound Tomas Jansson 23. Clinical Trials - Purpose and Procedures 24. Introduction to Patient Safety and Improvement Knowledge 25. Closing remarks

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Handbook of nuclear medicine and molecular imaging for physicists

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