Basics and regulatory principles
著者
書誌事項
Basics and regulatory principles
（Animal science, issues and research, . Nonhuman primate models in preclinical research ; v. 1）
Nova Science Publishers, c2021
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Due to the phylogenetic relationship and close genetic and biological similarities with humans, non-human primates (NHP) are regularly used in biomedical and behavioural research. However, because of their highly developed cognitive abilities and social skills, the use of these animals in biomedical research is debated more and more. Although it is acknowledged that in specific research areas NHP are still essential, it is recognised that the use of these animals can only be done under strict conditions under the most optimal welfare aspects. Welfare aspects include housing conditions, non-invasive methods and application of the 3Rs policy. Although many refinement methods have been described in nationally and internationally accepted guidelines on animal laboratory practice, recognition of the guidelines is unfortunately not universal. The present book covers a wide range of NHP models in preclinical research and welfare issues. The following chapters will cover: refinement of the use of NHP in biomedical research; NHP ethics and regulations in Europe; biological basis differences in the human and NHP; the major histocompatibility complex (MHC) immunology in NHP; stem cell biology in NHP; neuro and gliogenesis in an NHP ischemia stroke model; NHP models in autoimmune disease, organ transplantation and infectious disease research; viral diseases in NHP; NHP models in Parkinson's disease, in neurodegenerative disorders research and in cardio-cerebrovascular disease research; islet transplantation; ophthalmic diseases research and neurophysiology in NHP; transgenic engineering in NHP; NHP models of cancers; NHP models in respiratory disease research; NHP models in clinical and non-clinical pharmacology; NHP models in lung transplantation; and aging research in NHP. This book encapsulates a large volume of knowledge scientists have achieved in the field of nonhuman primate models in preclinical research. The editors have invited experts from the United States, Canada, and Europe to contribute 23 chapters in their respective fields of their expertise.
目次
- Foreword
- Preface
- Refinement of the Care and Use of NHPs in Biomedical Research
- Ethics and Legal Regulation of Nonhuman primates (NHPs) in Canada
- The Use of Nonhuman Primates: Ethics and Regulations in Europe
- Biological Basic Differences in the Human and NHPs
- MHC In NHP: From the Perspective of Immunogenetics
- Nonhuman Primate Stem Cell Biology
- NHP Models for Influenza
- Non-Human Primate Models of Human Autoimmune Diseases
- Nonhuman Primate Models in Organ Transplantation
- Modelling Malaria in NHPs Between 1900-2000
- Viral Diseases in NHPs
- NHP Models in Neurodegenerative Disorders Research
- Nonhuman Primate Models of Parkinsons Disease: Improvement in the Understanding of PD Progress and Development of Novel Therapy
- NHP Models of Cardio-Cerebrovascular Diseases Research
- Nonhuman Primate Models for Beta Cell Replacement in Diabetes Research
- Overview of Imaging Modalities for Nonhuman Primates
- Genetic Engineering in Nonhuman Primates and its Impact on Medical Science
- The Role of Nonhuman Primate (NHP) in Drug Safety Assessment
- The Nonhuman Primate as a Unique Model to Understand the Pathogenesis of Human Endometriosis
- NHP Models of Cancers
- Nonhuman Primates in Non-Clinical Development and Translational Research of Medicinal Products and Devices
- Nonhuman Primate (NHP) Models in Lung Transplantation
- Aging Research in Nonhuman Primates
- Index.
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