Dissipation and control in microscopic nonequilibrium systems
Author(s)
Bibliographic Information
Dissipation and control in microscopic nonequilibrium systems
（Springer theses : recognizing outstanding Ph. D. research）
Springer, c2021
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"Doctoral thesis accepted by Simon Fraser University, BC, Canada"
Includes bibliographical references
Description and Table of Contents
Description
This thesis establishes a multifaceted extension of the deterministic control framework that has been a workhorse of nonequilibrium statistical mechanics, to stochastic, discrete, and autonomous control mechanisms. This facilitates the application of ideas from stochastic thermodynamics to the understanding of molecular machines in nanotechnology and in living things. It also gives a scale on which to evaluate the nonequilibrium energetic efficiency of molecular machines, guidelines for designing effective synthetic machines, and a perspective on the engineering principles that govern efficient microscopic energy transduction far from equilibrium. The thesis also documents the author's design, analysis, and interpretation of the first experimental demonstration of the utility of this generally applicable method for designing energetically-efficient control in biomolecules. Protocols designed using this framework systematically reduced dissipation, when compared to naive protocols, in DNA hairpins across a wide range of experimental unfolding speeds and between sequences with wildly different physical characteristics.
Table of Contents
Chapter 1. Introduction.- Chapter 2. Theoretical background.- Chapter 3. DNA hairpins I: Calculating the generalized friction.- Chapter 4. DNA Hairpins II: reducing dissipation in nonequilibrium protocols.- Chapter 5. DNA Hairpins III: robustness, variability, and conclusions.- Chapter 6. Stochastic control in microscopic nonequilibrium systems.- Chapter 7. Optimal discrete control: minimizing dissipation in discretely driven systems.- Chapter 8. On dissipation bounds: discrete stochastic control of nonequilibrium systems.- Chapter 9. Free energy transduction within autonomous systems.- Chapter 10. Hidden excess power and autonomous Maxwell demons in strongly coupled nonequilibrium systems.- Chapter 11. Conclusions and outlook.
by "Nielsen BookData"
