Pharmacology of the Wnt Signaling System
著者
書誌事項
Pharmacology of the Wnt Signaling System
(Handbook of experimental pharmacology, 269)
Springer, c2021
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references
内容説明・目次
内容説明
This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of this evolutionarily conserved signaling system leads to many diseases including developmental disorders, diverse forms of cancer, fibrosis, neurodegenerative disease and many more. The WNT signaling system is built upon 19 mammalian, secreted WNT lipoglycoproteins that interact with a plethora of distinct receptors, such as the G protein-coupled receptors called Frizzleds (FZD1-10), LDL receptor-like proteins (LRP5/6), receptor tyrosine kinases (ROR1, 2, RYK and PTK7). In addition, WNT pathways are tightly regulated by many secreted and cell-intrinsic negative regulators, such as soluble FZD-related proteins (SFRPs), Dickkopfs (DKKs), WNT-inhibitory proteins, TIKI, RNF43 and more. Understanding the basic mechanism in terms of receptor-ligand interaction, receptor selectivity, signal initiation and desensitization remain poorly understood, even though substantial advances have been made the recent years. Due to the involvement of the WNT signaling system in human disease, it appears obvious to target diverse branches pharmacologically and therapeutically. However, given the complexity of the system and its importance for stem cell regulation and tissue maintenance, therapy comes with obvious risks for severe side effects. The field is addressing the challenge to identify suitable targets and selective compounds for therapy allowing disease-selective therapeutic effects and balancing unwanted side effects. This book summarizes the current understanding of the basic and applied pharmacology in the WNT signaling system and bridges disciplines such as pharmacology, physiology, neurosciences, oncology and drug development.
目次
Pharmacological thinking in WNT signaling.- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically.- WNTs on exosomes.- Strategies to target LRPs in WNT signaling.- Targeting the receptor tyrosine kinase ROR1 by small molecules.- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors.- Disheveled proteins as crucial mediators of WNT signaling.- Destruction complex and regulation of CTNNB1.- Strategies to therapeutically target WNT/PCP like signaling in disease.- Mining natural compounds to target WNT signaling - from mushrooms to corals.- FZD7 as a therapeutic target in intestinal cancer.- Targeting oncogenic WNT signaling with WNT derived peptides.- Targeting WNT signaling in lung pathology.- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting.- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy?.- Targeting WNT signaling as a risk.
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