Burger's medicinal chemistry, drug discovery and development

書誌事項

Burger's medicinal chemistry, drug discovery and development

J. Wiley

8th ed. / editor-in-chief, Donald J. Abraham ; consulting editor, Michael Myers

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内容説明・目次

内容説明

Burger's Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger's Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger's Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.

目次

PREFACE OF THE EDITOR-IN-CHIEF PREFACE OF THE CONSULTING EDITOR PREFACE OF THE VOLUME EDITOR CONTRIBUTORS Volume 1 : Methods in Drug Discovery 1 Chirality and Drug Discovery 2 Drug Discovery beyond the Rule of Five 3 Microbes to Man: From Soils and the Depths to Drugs as of early 2019 4 Fragment-Based Lead Discovery 5 Recent Advances in Development, Validation, and Exploitation of QSAR Models 6 Structure-Based Drug Design 7 Docking, Scoring and Virtual Screening in Drug Discovery 8 Computational Chemistry Tools 9 Assay Development and High-Throughput Screening 10 Advances in NMR-based Characterization of Drug Substances, Impurities, Degradants and Drug Metabolites 11 NMR-Based Screening and Drug Discovery 12 Mass Spectrometry and Drug Discovery 13 Cryo Electron Microscopy in Drug Discovery and Development: Opportunities and Challenges 14 Combinatorial Chemistry and Its Associated Technologies 15 Recent Advances in Chemistry Technologies and Applications to Medicinal Chemistry 16 Automated Synthesis 17 Artificial Intelligence in Medicinal Chemistry 18 Medicinal Chemical Biology Volume 2 : Lead Discovery in Drug Discovery 1 Ion Channels as Therapeutic Drug Targets 2 Drug Transport and Membrane Transport Proteins 3 Structure-Based Drug Design for G Protein-Coupled Receptors 4 Enzymes as Drug Targets 5 Allosterism & Drug Discovery 6 Nuclear Hormone Receptor Medicinal Chemistry 7 ADMET In Vitro Profiling Utility and Applications in Lead Discovery 8 Principles of Drug Metabolism 9 Advances in Multiobjective Optimization for Drug Discovery and Development 10 The Design and Application of Bioisosteres in Drug Design 11 Structure Alerts in Medicinal Chemistry (original chapter: Structural Alerts for Toxicity) Volume 3 : Development 1 Intellectual Property for Biotechnology and Pharmaceutical Products 2 Experiences in Academic and Industry Partnerships Forging a Path to Translational Drug Discovery 3 Large-Scale Synthesis 4 Preparative Chromatography for Production 5 Translational Pharmaceutics and Early Phase Clinical Development 6 Salt Screening and Selection 7 Polymorphic Crystal Forms in Drug Delivery (Crystal Engineering) 8 Physicochemical Characterization and Oral Dosage Form Design and Selection 9 Prodrugs: Strategic Deployment, Metabolic Considerations, and Chemical Design Principles 10 Provisional BCS Classification of Leading Oral Drugs in Global Market 11 Process Development of Protein Therapeutics 12 Role of Permeability in Drug ADME, PK Interactions and Toxicity 13 Toxicology and Nonclinical Safety Assessment in Pharmaceutical Discovery and Development 14 Quality Assurance 15 The FDA and Drug Regulatory Issues 16 FDA-Approved Medicines 17 Clinical Development - A Primer 18 Global Health Outcomes and Real World Evidence a Primer 19 A Brief Primer on Project Leadership, Project Management and Cross-Functional Teams Volume 4 : Cardiovascular, Endocrine and Metabolic Diseases 1 Dipeptidyl Peptidase 4 Inhibitors 2 Glucagon Like Peptide 1 Receptor Activators 3 Sodium Glucose Co-Transporter Inhibitors for the Treatment of Diabetes 4 Treatments for Non-Alcoholic Steatohepatitis (NASH) 5 Therapeutic Strategies for Sickle Cell Disease 6 Hematopoietic Agents 7 Anticoagulants 8 Antiplatelet Agents (needs proofreading, few minor changes needs to be done by the author. 9 Atherosclerosis: Cholesterol Management (original: Atherosclerosis I: LDL Cholesterol Lowering) 10 Recent Advances Toward New Small Molecule Therapies for Heart Failure 11 ACE Inhibitors Volume 5 : Inflammation, Pulmonary, Bone, Immunology Agents and Vitamins 1 Fundamentals of Steroid Chemistry and Biochemistry 2 Estrogen Receptor Modulators (original chapter: Female Sex Hormones, Contraceptives, And Fertility Drugs by Peter C. Ruenitz) 3 Modulation of the Androgen Receptor Axis bmc055 (original chapter: Male Sex Hormones, Analogs, and Antagonists) 4 Essential Micronutrients: Vitamins and Essential Fatty Acids 5 Current and Emerging Therapies in Pulmonary Disease 6 Anti-Inflammatory Glucocorticoids and Receptors 7 Osteoporosis Therapy: Mechanistic Antiresorptives 8 Osteoporosis: Current and Future Anabolic Therapy 9 Drug Discovery in Erectile Dysfunction and Sleep Disorders (original chapter: Drug Discovery in Non-Life-Threatening Disorders: Erectile Dysfunction, Insomnia, and Smoking) 10 Multiple Sclerosis 11 JAK Inhibitors for Autoimmune Diseases 12 Eicosanoid Pathway Modulators: Prostaglandins, Prostacyclins and Thromboxanes Volume 6 : Cancer 1 Synthetic DNA Target Therapeutics 2 USFDA-Approved Small-Molecule Kinase Inhibitors for Cancer Therapy (original chapter: Kinase Inhibitors: Approved Drugs and Clinical Candidates) 3 Cancer Drug Resistance: Targets and Therapies 4 Natural Products as Cytotoxic Agents 5 Tumor Metabolism: Focused on Tumor Glycolysis, Progress and Prospects in Cancer Therapy 6 Small-Molecule Effectors of DNA Repair Proteins: applications for development of cancer therapeutics and research 7 Angiogenesis Inhibitors 8 Cancer Targets Involving the Ubiquitin Proteasome System 9 Immuno-oncology 10 The Design and Development of Antibody-Drug Conjugates (ADCs) for the Treatment of Cancer 11 Hsp90 Inhibitors 12 Gene Therapy with Plasmid DNA Volume 7 : Antiinfectives 1 Confronting the COVID-19 Pandemic: December 2019 - May 2020 2 Medicinal Chemistry of -Lactam Antibiotics 3 2010 to 2020: ten years of malaria drug discovery 4 Drug Discovery and Development for Kinetoplastid Diseases 5 Anti-DNA Virus Agents 6 Polymyxins as Antibacterials and Antibiotic Potentiators 7 Antifungal Drugs 8 The Gut Microbiome 9 Antitubercular Agents 10 Bacterial Efflux Pumps and Their Inhibitors 11 Current Status of Approaches to Eradicate HIV Infection 12 Antiinfective Case Histories Volume 8 : CNS 1 Cholinergics/Anticholinergics 2 Therapeutic and Diagnostic Agents for Parkinson's Disease 3 Opioid Receptor Ligands 4 Antipsychotic Agents 5 Antidepressants 6 PET and SPECT in Drug Development 7 New and Emerging Antiepileptic Drugs 8 Cognition 9 The Blood-brain Barrier and CNS Drug Delivery INDEX

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関連文献: 8件中  1-8を表示

  • CNS disorders

    volume editor, Richard A. Glennon

    J. Wiley 2021 8th ed Burger's medicinal chemistry, drug discovery and development v. 8

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  • Anti-infectives

    volume editor, Roland E. Dolle

    J. Wiley 2021 8th ed Burger's medicinal chemistry, drug discovery and development v. 7

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  • Cancer

    volume editors, Barry Gold, Donna M. Huryn

    J. Wiley 2021 8th ed Burger's medicinal chemistry, drug discovery and development v. 6

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  • Pulmonary, bone, immunology, vitamins, and autocoid therapeutic agents

    volume editor, Bryan H. Norman

    J. Wiley 2021 8th ed Burger's medicinal chemistry, drug discovery and development v. 5

    所蔵館3館

  • Cardiovascular, endocrine, and metabolic diseases

    volume editor, Scott D. Edmondson

    J. Wiley 2021 8th ed Burger's medicinal chemistry, drug discovery and development v. 4

    所蔵館3館

  • Drug development

    volume editors, Ramnarayan S. Randad, Michael Myers

    J. Wiley 2021 8th ed Burger's medicinal chemistry, drug discovery and development v. 3

    所蔵館3館

  • Discovering lead molecules

    volume editor, Kent D. Stewart

    J. Wiley 2021 8th ed Burger's medicinal chemistry, drug discovery and development v. 2

    所蔵館3館

  • Methods in drug discovery

    volume editor, Kent D. Stewart

    J. Wiley 2021 8th ed Burger's medicinal chemistry, drug discovery and development v. 1

    所蔵館3館

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