The ADME encyclopedia : a comprehensive guide on biopharmacy and pharmacokinetics

著者

• Talevi, Alan

書誌事項

The ADME encyclopedia : a comprehensive guide on biopharmacy and pharmacokinetics

edited by Alan Talevi

Springer, 2022

• hbk.

内容説明・目次

内容説明

The ADME Encyclopedia covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge, serving as introductory material for students of biomedical careers and also as reference, updated material for graduates and professionals working in any field related to pharmaceutical sciences (medicine, pharmaceutical technology, materials science, medicinal chemistry). Structured as alphabetically ordered entries with cross-references, the Encyclopedia not only provides basic knowledge on ADME processes, but also detailed entries on some advanced subjects such as drug transporters, last generation pharmaceutical carriers, pharmacogenomics, personalized medicine, bioequivalence studies, biowaivers, biopharmaceuticals, gene delivery, pharmacometrics, pharmacokinetic drug interactions or in silico and in vitro assessment of ADME properties

目次

Drug dissolution and drug release Mathematical models of drug dissolution and drug release Diffusion layer model Danckwert's model Interfacial barrier model First order model Higuchi model Korsmeyer-Peppas model Hixson-Crowell model Baker-Lonsdale model Weibull model In vitro dissolution testing Modalities of dissolution tests Biorelevant dissolution media Drug absorption Free diffusion Facilitated diffusion Active transport Transcytosis pH partition theory pKa determination Factors impacting drug absorption Drug distribution Factors impacting drug distribution Real volume of distribution Apparent volume of distribution Drug binding to plasma proteins Drug displacement Non-linear binding to plasma proteins Drug binding to tissue components One-compartment pharmacokinetic model Two-compartment pharmacokinetic model Central nervous system bioavailability Blood-brain barrier log BB Kpuu Drug metabolism Functionalization reactions Synthetic reactions Cytochrome P450 Phase III reactions Factors impacting on drug metabolism Genetic variants. Polymorphism Age Gender Environmental factors: enzyme induction Precision medicine Pharmacogenomic DNA chips Microsomes Drug excretion Biliary excretion Enterohepatic recycling Enterohepatic recycling and antibiotics Renal excretion Glomerular filtration Tubular reabsorption Tubular secretion Clearance Organ clearance Routes of administration Oral route Migrating motor complex Enteric coating tablets Food-drug interactions Gastric emptying Gastroretentive drug delivery systems Multiparticulate drug delivery systems Gut microbiota Lipinski rule of five Permeation enhancers Intestinal perfusion models Bucal and sublingual route Rectal route Intravenous route Intravenous bolus Intravenous infusion Technological considerations for intravenous administration Intramuscular administration Subcutaneous administration Specialized parenteral routes Pulmonary administration Nasal administration Transdermal administration Permeation enhancers Next generation drug delivery systems Nanocarriers Surface-to-volume ratio Surface chemistry Nanotoxicology Drug release from nanocarriers Passive targeting Smart systems / stimuli-responsive systems Active targeting Mononuclear phagocyte system Absorption and distribution of nanocarriers Elimination of nanocarriers PEGylationADME Viral vectors Pharmacogenomics Enzyme polymorphism Transporter polymorphism Pharmacogenomics and pediatrics Bioavailability and bioequivalence Bioavailability Systemic bioavailability Generic drugs Post-approval changes Bioequivalence Absolute bioavailability Mass balance studies Bioequivalence studies Reference and test products Biopharmaceutical Classification System Biowaivers BCS subclasses Dissolution testing Pharmacodynamic studies Biopharmaceutical drug products Absorption of protein drugs Distribution of protein drugs Elimination of protein drugs ADME properties of insulins ADME properties of heparins ADME properties of gene-based biopharmaceuticals Drug-drug and food-drug interactions Plasma protein binding DDI Membrane transport DDI Metabolism DDI FDI based on induction of gastrointestinal changes In vitro and in silico ADME predictions Polarized cell lines Caco-2 MDCK Solubility Dissolution testing QSPR/QSAR Expert rules Central Nervous System Multiparameter Optimization Dynamic transit models Sandwich-cultured hepatocytes Single-cell expression systems Membrane vesicles Molecular dynamics simulations Drug tansporters ABC transporters MDR1 MRPs BCRP Solute carriers Organic anion transporters Organic cation transporters Peptide transporters Non-linear pharmacokinetics Linear pharmacokinetics Positive deviations from linear behavior Negative deviations from linear behavior Time-dependent pharmacokinetics Pharmacometrics and physiologic models

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BC12895359
• ISBN:
  • 9783030848590
• 出版国コード: sz
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Cham
• ページ数/冊数: 1 volume
• 大きさ: 26 cm
• 分類:
  • DC23 : 615.7
• 件名:
  • LCSH : Pharmacokinetics
  • LCSH : Pharmaceutical technology