Tamoxifen : molecular basis of use in cancer treatment and prevention
著者
書誌事項
Tamoxifen : molecular basis of use in cancer treatment and prevention
John Wiley, c1994
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内容説明・目次
内容説明
Currently there is considerable interest in the uses of tamoxifen not only to treat breast cancer but also to prevent it. Its potential as a major chemopreventative agent has attracted controversy relating to the possible harmful side-effects of tamoxifen therapy but also to its potential to protect against other cancers, cardiovascular disease and osteoporosis. This book explains the molecular basis of the action of tamoxifen, knowledge of which is vital to the understanding of its present uses and future potential, particularly in relation to the development of new derivatives. The book is a fully integrated, extensively referenced account of a wide range of topics relevent to the clinical use of tamoxifen, providing a comprehensive guide for those working in clinical and biomedical research within the pharmaceutical industry and in the fields of biochemistry, pharmacology, nutrition, oncology, toxicology, molecular and cellular biology, pharmacy, and obstetrics and gynaecology. The book's readable also makes it accessible to medical practitioners and students of medicine and biology.
目次
The Importance of Understanding the Anticancer Action of Tamoxifen at a Molecular Level. An Introduction to the Chemistry and Pharmacology of Tamoxifen. Metabolism and Toxicology of Tamoxifen: An Overview. An Overview of the Clinical Use of Tamoxifen in the Treatment and Prevention of Breast Cancer. Oestrogen Receptor-Mediated Mechanisms of Anticancer Action of Tamoxifen. Modulation by Tamoxifen of Oncogenes and Growth Factors and the Problem of Tamoxifen Resistance in Breast Cancer. Inhibitory Action of Tamoxifen on Enzymes Involved in the Synthesis of Oestrogens and in Signal Transduction: Importance to Anticancer Action?. Antioxidant Action of Tamoxifen in Membranes and Lipoprotein Particles: Role in the Anticancer, Anti-Multidrug Resistance and Cardioprotective Actions of Tamoxifen. Inhibitory Action of Tamoxifen in a Yeast Tumour Model and the Potential Anti-Candida and Antiviral Use of Tamoxifen. Tamoxifen: Brief Outline of Future Possibilities in Disease Control in Relation to Drug Design Strategies. Index.
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