Fundamentals of forensic DNA typing

著者

書誌事項

Fundamentals of forensic DNA typing

John M. Butler

Academic Press, an imprint of Elsevier, c2010

  • : pbk

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注記

Based on author's Forensic DNA typing : biology & technology behind STR markers. c2001

Includes bibliographical references and index

内容説明・目次

内容説明

Fundamentals of Forensic DNA Typing is written with a broad viewpoint. It examines the methods of current forensic DNA typing, focusing on short tandem repeats (STRs). It encompasses current forensic DNA analysis methods, as well as biology, technology and genetic interpretation. This book reviews the methods of forensic DNA testing used in the first two decades since early 1980's, and it offers perspectives on future trends in this field, including new genetic markers and new technologies. Furthermore, it explains the process of DNA testing from collection of samples through DNA extraction, DNA quantitation, DNA amplification, and statistical interpretation. The book also discusses DNA databases, which play an important role in law enforcement investigations. In addition, there is a discussion about ethical concerns in retaining DNA profiles and the issues involved when people use a database to search for close relatives. Students of forensic DNA analysis, forensic scientists, and members of the law enforcement and legal professions who want to know more about STR typing will find this book invaluable.

目次

Foreword Introduction Acknowledgments About the author 1 Overview and History of DNA Typing 2 Basics of DNA Biology and Genetics 3 Historical Methods 4 Sample Collection, Storage and Characterization 5 DNA Extraction 6 DNA Quantitation 7 DNA Amplification (The Polymerase Chain Reaction) 8 Short Tandem Repeat Markers 9 Fundamentals of DNA separation and Detection 10 STR Genotyping and Data Interpretation 11 Statistical Interpretation: Evaluating the Strength of Forensic DNA Evidence 12 DNA databases 13 Quality Assurance 14 Forensic Challenges: Degraded DNA, Mixtures, and LCN 15 Additional Loci and Non-Human DNA Testing 16 Lineage Markers: Y Chromosome and mtDNA Testing 17 Applications of DNA Typing 18 Future Trends Appendix 1 Glossary of Terms 2 Useful Websites 3 Probability and Statistics

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