Fluorine and health : molecular imaging, biomedical materials and pharmaceuticals

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Fluorine and health : molecular imaging, biomedical materials and pharmaceuticals

edited by Alain Tressaud, Günter Haufe

Elsevier, 2008

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized.

目次

PART I: MOLECULAR IMAGING 1. Fluorine-18 Chemistry for Molecular Imaging with Positron Emission Tomography Frederic Dolle, Dirk Roeda, Bertrand Kuhnast, and Marie-Claire Lasne 2. Application of 18F-PET Imaging for the Study of Alzheimer's Disease Kjell Nagren and Juha O. Rinne 3. 18F-Labeled PET-Tracers for Cardiological Imaging Klaus Kopka, Stefan Wagner, Michael Schafers, Andreas Faust, Otmar Schober, and Gunter Haufe 4. [18F]-Labeled PET and PET/CT Compounds in Oncology Ken Herrmann and Bernd Joachim Krause 5. Non-Invasive Physiology and Pharmacology Using 19F Magnetic Resonance Jian-Xin Yu, Weina Cui, Dawen Zhao, and Ralph P. Mason PART II: BIOMEDICAL MATERIALS 6. Fluoride-Based Bioceramics Christian Rey, Christele Combes, Christophe Drouet, and Hocine Sfihi 7. Fluoride in Dentistry and Dental Restoratives John W. Nicholson and Beata Czarnecka 8. Fluorinated Biomaterials for Cardiovascular Surgery Charles Baquey, Marie-Christine Durrieu, and Robert G. Guidoin 9. Fluorinated Molecules in Eye Surgery: Experimental and Clinical Benefit of a Heavy Silicone Oil Oxane Hd (R) (Mixture of Silicone Oil and RMN3 Fluorine Olefin) in the Treatment of Retinal Detachment I. Rico-Lattes, J. C. Quintyn, V. Pagot-Mathis, X. Benouaich, and A. Mathis 10. Biocompatibility of Highly Fluorinated Liquids Used in Ophthalmic Surgery Dirk-Henning Menz and Joachim H. Dresp 11. Perfluorochemical-Based Oxygen Therapeutics, Contrast Agents, and Beyond Marie Pierre Krafft and Jean G. Riess 12. Exposure of Humans to Fluorine and Its Assessment Maja Ponikvar PART III: PHARMACEUTICALS 13. Biological Impacts of Fluorination: Pharmaceuticals Based on Natural Products Jean-Pierre Begue and Daniele Bonnet-Delpon 14. Synthesis and Pharmacological Properties of Fluorinated Prostanoids Yasushi Matsumura 15. Synthesis and Biochemical Evaluation of Fluorinated Monoamine Oxidase Inhibitors Kenneth L. Kirk, Shinichi Yoshida, and Gunter Haufe 16. Fluoroolefin Dipeptide Isosteres: Structure, Syntheses, and Applications John T. Welch 17. Molecular Interactions of Fluorinated Amino Acids in a Native Polypeptide Environment Mario Salwiczek, Christian Jackel, and Beate Koksch 18. Biological Fluorination in Streptomyces cattleya: The Fluorinase Hai Deng, Fang-Lu Huang, James H. Naismith, David O'Hagan, Jonathan B. Spencer, and Xiaofeng Zhu

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