Targeting Mitochondria
Author(s)
Bibliographic Information
Targeting Mitochondria
（Methods in molecular biology / John M. Walker, series editor, 2275 . Mitochondrial Medicine ; v. 1）（Springer protocols）
Humana Press, c2021
2nd ed
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume I guides readers through chapters on QSAR models, DQAsomes, synthesis of Triphenylphosphonium Phospholipid Conjugates, testing of novel isomeric mitochondriotropic derivatives, mTRIP, mitochondria-targeted imaging nanoplatforms, live-cell assessment, mitochondrial coenzyme Q10, rat liver Mitochondrial Lipidome, and Mito-SinCe2. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 1: Targeting Mitochondria aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.
Table of Contents
1. Using QSAR Models to Predict Mitochondrial Targeting by Small Molecule Xenobiotics within Living CellsRichard W. Horobin
2. DQAsomes as the Prototype of Mitochondria-targeted Pharmaceutical Nanocarriers: An Update
Volkmar Weissig, Maria Lozoya, Nusem Yu, and Gerard G.M. D'Souza
3. Synthesis and Characterization of Mitochondria-Targeted Triphenyltriphenylphosphonium Bolaamphiphiles
Francesca Ceccacci, Simona Sennato, Edoardo Rossi, Raffaele Proroga, Stefano Sarti, Marco Diociaiuti, Stefano Casciardi, Valentina Mussi, Alessia Ciogli, Federico Bordi, Giovanna Mancini, and Cecilia Bombelli
4. Synthesis and Evaluation of 18F-labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging
Dong-Yeon Kim and Jung-Joon Min
5. Novel Mitochondria-Targeted Triphenylphosphonium Conjugates of Linear beta-Phosphorylated Nitrones: Preparation, 31P NMR Mitochondrial Distribution, EPR Spin Trapping Reporting, and Site-Directed Anti-Apoptotic Properties
Consuelo Petrocchi, Sophie Thetiot-Laurent, Marcel Culcasi, and Sylvia Pietri
6. Insights on Targeting Small Molecules to the Mitochondrial Matrix and the Preparation of MitoB and MitoP as exomarkers of Mitochondrial Hydrogen Peroxide
Andrew G. Cairns, Stephen J. McQuaker, Michael P. Murphy, and Richard C. Hartley
7. Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes
Parul Benien, Mohammed Almuteri, Shrey Shah, Mark Boehlke, Ahmed Mehanna, and Gerard G. M. D'Souza
8. Imaging Mitochondrial Hydrogen Peroxide in Living Cells
Alexander R. Lippert, Bryan C. Dickinson, and Elizabeth J. New
9. Synthesis and Testing Of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin
Lucia Biasutto, Andrea Mattarei, and Cristina Paradisi
10. Bridging the Gap between Nature and Antioxidant Setbacks: Delivering Gallic Acid to Mitochondria
Fernando Cagide, Catarina Oliveira, Jose Teixeira, Paulo J. Oliveira, and Fernanda Borges
11. Liposomal Delivery of Cyclocreatine Impairs Cancer Cell Bioenergetics Mediating Apoptosis
Samayita Ganguly and Tamer Elbayoumi
12. Mt-fura-2, a ratiometric Mitochondria-targeted Ca2+ sensor. Determination of spectroscopic properties and Ca2+ Imaging Assays
Andrea De Nadai, Nicola Vajente, Diana Pendin, and Andrea Mattarei
13. Sequence-Specific Control of Mitochondrial Gene Transcription using Programmable Synthetic Gene Switches called MITO-PIPs
Takuya Hidaka, Hiroshi Sugiyama, and Ganesh N. Pandian
14. Targeting the Mitochondrial Genome via a MITO-Porter: Evaluation of mtDNA and mtRNA Levels and Mitochondrial Function
Yuma Yamada and Hideyoshi Harashima
15. mTRIP, an Imaging Tool to Investigate Mitochondrial DNA dynamics in Physiology and Disease at the Single-Cell Resolution
Laurent Chatre and Miria Ricchetti
16. Development of Mitochondria-Targeted Imaging Nanoplatforms by Incorporation of Fluorescent Carbon Quantum Dots
Ye Zhang and Hong Bi
17. Norbormide-based Probes and their Application for Mitochondrial Imaging in Drosophila Melanogaster
Alessia Forgiarini , Zifei Wang , Sergio Bova, Margaret Anne Brimble, Brian Hopkins 3, David Rennison, and Genny Orso
18. Live-cell Assessment of Reactive Oxygen Species Levels Using Dihydroethidine
Sander Grefte and Werner J.H. Koopman
19. Protein Supercomplex Recording In Living Cells Via Position-Specific Fluorescence Lifetime Sensors
Bettina Rieger and Karin B. Busch
20. Identification of Peroxynitrite by Profiling Oxidation and Nitration Products from Mitochondria-Targeted Arylboronic Acid
Jacek Zielonka, Adam Sikora, Radoslaw Podsiadly, Micael Hardy, and B. Kalyanaraman
21. Mitochondrial Coenzyme Q10 Determination via Isotope Dilution Liquid Chromatography Tandem Mass Spectrometry
Erik Hedman and Outi Itkonen
22. Janus-type Mesoporous Silica Nanoparticles for Sequential Tumoral Cell and Mitochondria Targeting
Maria Rocio Villegas, Victoria Lopez, Veronica Rodriguez-Garcia, Alejandro Baeza, and Maria Vallet-Regi
23. Split Green Fluorescent Protein-Based Contact Site Sensor (SPLICS) for Heterotypic Organelle Juxtaposition as Applied to ER - Mitochondria Proximities
Tito Cali and Marisa Brini
24. Qualitative Characterization of the Rat liver Mitochondrial Lipidome using All Ion Fragmentation on an Exactive Benchtop Orbitrap MS
Irina G. Stavrovskaya, Rose M. Gathungu, Susan S. Bird, and Bruce S. Kristal
25. Live Imaging of Mitochondria in Kidney Tissue
Milica Bugarski, Susan Ghazi, and Andrew M Hall
26. Time-resolved Imaging of Mitochondrial Flavin Fluorescence and Its Applications for Evaluating the Oxidative State in Living Cardiac Cells
Marcek Chorvatova A., Cagalinec M., and Chorvat D Jr.
27. Mito-SinCe2 Approach to Analyze Mitochondrial Structure-Function In Single Cells
Spurlock B and Mitra K
28. Computer-aided Prediction of Protein Mitochondrial Localization
Pier Luigi Martelli, Castrense Savojardo, Piero Fariselli, Giacomo Tartari, and Rita Casadio
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