Manipulating mitochondria and disease-specific approaches

Author(s)

Bibliographic Information

Manipulating mitochondria and disease-specific approaches

edited by Volkmar Weissig, Marvin Edeas

(Methods in molecular biology / John M. Walker, series editor, 2277 . Mitochondrial Medicine ; v. 3)(Springer protocols)

Humana Press, c2021

2nd ed

Available at  / 2 libraries

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Includes bibliographical references and index

Description and Table of Contents

Description

This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume III guides readers through chapters on intercellular mitochondrial transfer, Cytoplasmic transfer methods, Ndufs4 knockout mouse, in vivo assessment of mitochondrial oxygen consumption, mitochondrial network analysis by imaging, mitochondrial respiration in platelets, Heterologous Inferential Analysis (HIA), bioenergetic profiling, integrative methods for studying cardiac energetics, and isolation and deep sequencing of mitochondrial DNA.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 3: Manipulating Mitochondria and Disease- Specific Approaches aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

Table of Contents

1. Allotopic Expression of ATP6 in the Mouse as a Transgenic Model of Mitochondrial Disease David A. Dunn and Carl A. Pinkert 2. Mitochondrial Transplantation for Ischemia Reperfusion Injury Ilias P. Doulamis and James D. McCully 3. Quantitatively Controlled Intercellular Mitochondrial Transfer by Cell Fusion-Based Method Using a Microfluidic Device Ken-Ichi Wada, Kazuo Hosokawa, Yoshihiro Ito, and Mizuo Maeda 4. Lipophilic Conjugates for Carrier-Free Delivery of RNA Importable Into Human Mitochondria Ilya Dovydenko, Mariya Meschaninova, Anne-Marie Heckel, Ivan Tarassov, Alya Venyaminova, and Nina Entelis 5. Drug Discovery Assay to Identify Modulators of the Mitochondrial Ca2+ Uniporter Daniela M. Arduino, Valerie Goh, Dejana Mokranjac, and Fabiana Perocchi 6. Cytoplasmic Transfer Methods for Studying the Segregation of Mitochondrial DNA in Mice Thomas Kolbe, Ralf Steinborn, and Joerg P. Burgstaller 7. Electron Attachment to Isolated Molecules as a Probe To Understand Mitochondrial Reductive Processes Stanislav A. Pshenichnyuk and Alberto Modelli 8. Assessment of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation Matthias Hecker, Natascha Sommer, and Konstantin Mayer 9. Assessment of the Effects of Drugs on Mitochondrial Respiration Jana Hroudova and Zdenek Fisar 10. The Ndufs4 Knockout Mouse: A Dual Threat Model of Childhood Mitochondrial Disease and Normative Aging Anthony S. Grillo, Alessandro Bitto, and Matt Kaeberlein 11. Suborganellar Localisation of Mitochondrial Proteins and Transcripts in Human Cells Anna Smirnova, Ludovic Richert, Alexandre Smirnov, Yves Mely, and Ivan Tarassov 12. In vivo Assessment of Mitochondrial Oxygen Consumption Floor A. Harms and Egbert G. Mik 13. Update of Mitochondrial Network Analysis by Imaging: Proof of Technique in Schizophrenia Yekaterina Yatchenko and Dorit Ben-Shachar 14. Heterologous Inferential Analysis (HIA) and other Emerging Concepts In Understanding Mitochondrial Variation in Pathogenesis: There is no More Low Hanging Fruit Anton Vila-Sanjurjo, Paul M. Smith, and Joanna L. Elson 15. Accurate Measurement of Cellular and Cell-Free Circulating Mitochondrial DNA Content from Human Blood Samples Using Real Time Quantitative PCR Hannah Rosa and Afshan Malik 16. Measurement of Mitochondrial Respiration in Platelets Zdenek Fisar and Jana Hroudova 17. Isolation and Electron Microscopic Analysis of Liver Cancer Cell Mitochondria Yaschar Kabiri, Carola Eberhagen, Sabine Schmitt, Percy A. Knolle, and Hans Zischka 18. Assessment of Mitochondrial Reactive Oxygen Species and Redox Regulation in Stem Cells Madhavee Thumiah-Mootoo, Tina Podinic, and Mireille Khacho 19. Single Cell Approaches for Studying the Role of Mitochondrial DNA in Neurodegenerative Disease Laura J. Bailey, Joanna L. Elson, and Ilse S. Pienaar 20. A New Method for Sequencing the Mitochondrial Genome by Using Long Read Technology Sophie Dhorne-Pollet, Nicolas Pollet, and Eric Barrey 21. Mitochondrial DNA as a Sensitive Biomarker of UV-induced Cellular Damage in Human Skin Amy Bowman and Mark A. Birch-Machin 22. Isolation of Mitochondria-associated ER Membranes (MAMs), Synaptic MAMs and Glycosphingolipid Enriched Microdomains (GEMs) from Brain Tissues and Neuronal Cells Ida Annunziata, Jason Andrew Weesner, and Alessandra d'Azzo 23. Mitochondrial Diagnostics: A Discovery-Based Biochemical Platform for Phenotyping Human Peripheral Blood Cell Mitochondria Margaret A. M. Nelson and Kelsey H. Fisher-Wellman 24. Bioenergetic Profiling Of Human Pluripotent Stem Cells Gizem Inak-Girrbach, Marie-Therese Henke, and Alessandro Prigione 25. Integrative Methods for Studying Cardiac Energetics Philippe Diolez, Veronique Deschodt-Arsac, Guillaume Calmettes, Gilles Gouspillou, Laurent Arsac, Pierre Jais, Michel Haissaguerre, and Pierre dos Santos 26. Isolation of Mitochondria from Retinal Pigment Epithelial Cell Cultures and an Application Of High Resolution Respirometric Assay (XFe96 Seahorse assay) Masaaki Ishii, Gyda Beeson, Craig Beeson, and Barbel Rohrer 27. The Isolation and Deep Sequencing of Mitochondrial DNA Alexander G. Bury, Fiona M. Robertson, Angela Pyle, Brendan A. I. Payne, and Gavin Hudson 28. Ultrastructure of the Mitochondria-Associated Membranes in Human Tumor Specimens Gabriel Arismendi-Morillo

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Details

  • NCID
    BC14566187
  • ISBN
    • 9781071612699
  • Country Code
    us
  • Title Language Code
    eng
  • Text Language Code
    eng
  • Place of Publication
    New York
  • Pages/Volumes
    xv, 468 p.
  • Size
    27 cm
  • Classification
  • Subject Headings
  • Parent Bibliography ID
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