Systems biology
Author(s)
Bibliographic Information
Systems biology
（Methods in molecular biology / John M. Walker, series editor, 1702）（Springer protocols）
Humana Press/Springer Science + Business Media, 2018
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
This volume focuses on methodological aspects of systems biology in order to provide a new theoretical approach with a robust and tailored experimental support. Chapters detail mathematical modeling, methodological issues, modulation of the collective behavior, metabolic, dynamic profiling, and quantitative morphological studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Systems Biology aims to ensure successful results in the further study of this vital field.
Table of Contents
- 1. Conceptual Challenges in the Theoretical Foundations of Systems Biology Marta Bertolaso and Emanuele Ratti 2. An Integrative Approach toward Biology, Organism s, and Cancer Carlos Sonnenschein and Ana M. Soto 3. Conceptual Challenges of the Systemic Approach in Understanding Cell Differentiation Andras Pald i 4. A Primer on Mathematical Modeling in the Study of Organisms and their Parts Mael Montevil 5. The Search for System's Parameters Alessandro Giuliani 6 . Inverse Problems in Systems Biology: A Critical Review Rodolfo Guzzi, Teresa Colombo, and Paola Paci 7. Systems Biology Approach and Mathematical Modeling for Analyzing Phase-space Switch during Epithe lial-mesenchymal Transition Chiara Simeoni, Simona Dinicolab, Alessandra Cucina, Corrado Mascia, and Mariano Bizzarri 8. Parameters Estimation in Phase-space Landscape Reconstruction of Cell Fate
- A Systems Biology Approach S. Montero, R.R. Martin, R. Mansilla, G. Cocho, and J.M. Nieto-Villar 9. Complexity of Biochemical and Genetic Responses Reduced using Simple Theoretical Models Kumar Selvarajoo 10. Systems Biology Modelling of Non-linear Cancer Dynamics Christian Cherubini, Simonetta Filippi, and Alessandro Loppini 11. Endogenous Molecular-cellular Network Cancer Theory: A Systems Biology Approach Gaowei Wang, Ruoshi Yuan, Xiaomei Zhu, and Ping Ao 12. A Network-based Integrative Workflow to Unravel Mechanisms Underlying Disease Progression Faiz M. Khan, Mehdi Sadeghi, Shailendra K. Gupta, and Olaf Wolkenhauer 13. Spatiotemporal Fluctuation Analysis of Molecular Diffusion Laws in Live-cell Membranes Francesco Cardarelli 14. A Method for Cross-species Visualization and Analysis of RNA-sequence Data Stephen A. Ramsey 15. Multi Agent Simulations of Population Behavior (A Promising Tool for Systems Biology) Alfredo Colosimo 16. Metabolomics: Challenges and Opportunities in Systems Biology Studies Luca Casadei, Mariacristina Valerio, and Cesare Manetti 17. Systems Biology-driven Hypotheses Tested In Vivo: The Need to Advancing Molecular Imaging Tools Garima Verma, Alessandro Palombo, Maura Grigioni, Morena La Monaca, and Giuseppe D'Avenio
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