Genome-wide association studies
著者
書誌事項
Genome-wide association studies
(Methods in molecular biology / edited by John M. Walker, 2481)
Humana Press, c2022
大学図書館所蔵 全2件
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This detailed collection explores genome-wide association studies (GWAS), which have revolutionized the investigation of complex traits over the past decade and have unveiled numerous useful genotype-phenotype associations in plants. The book describes the key concepts and methods underlying GWAS, including the genetic architecture underlying variation for phenotypic traits, the structure of genetic variation in plants, technologies for capturing genetic information, study designs, and the statistical models and bioinformatics tools used for data analysis. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of invaluable implementation advice that leads to the most fruitful research results.
Authoritative and practical, Genome-Wide Association Studies serves as an extremely valuable resource for the plant research community by rendering GWAS analysis less challenging and more accessible to a broader group of users.
目次
Part I: Reviews and Overviews
1. Designing a Genome-Wide Association Study: Main Steps and Critical Decisions
Francois Belzile and Davoud Torkamaneh
2. Preparation and Curation of Phenotypic Datasets
Santiago Alvarez Prado, Fernando Hernandez, Ana Laura Achilli, and Agustina Amelong
3. Genotyping Platforms for Genome-Wide Association Studies: Options and Practical Considerations
David L. Hyten
4. Genome-Wide Association Study Statistical Models: A Review
Mohsen Yoosefzadeh-Najafabadi, Milad Eskandari, Francois Belzile, and Davoud Torkamaneh
5. Interpretation of Manhattan Plots and Other Outputs of Genome-Wide Association Studies
Jiabo Wang, Jianming Yu, Alexander E. Lipka, and Zhiwu Zhang
Part II: Phenotypic Data for GWAS
6. Preparation and Curation of Multi-Year, Multi-Location, Multi-Trait Datasets
Amina Abed and Zakaria Kehel
7. Development, Preparation, and Curation of High-Throughput Phenotypic Data for Genome-Wide Association Studies: A Sample Pipeline in R
Pasquale Tripodi
8. Preparation and Curation of Omics Data for Genome-Wide Association Studies
Feng Zhu, Alisdair R. Fernie, and Federico Scossa
Part III: Genotypic Data and Assessment of Population Structure
9. Producing High-Quality Single Nucleotide Polymorphism Data for Genome-Wide Association Studies
Philipp E. Bayer, Mitchell Gill, Monica F. Danilevicz, and David Edwards
10. A Practical Guide to Using Structural Variants for Genome-Wide Association Studies
Marc-Andre Lemay and Sidiki Malle
11. Data Integration, Imputation, and Meta-Analysis for Genome-Wide Association Studies
Reem Joukhadar and Hans D. Daetwyler
12. Population Structure and Relatedness for Genome-Wide Association Studies
Sidiki Malle
Part IV: Bioinformatics Tools for GWAS
13. Performing Genome-Wide Association Studies with Multiple Models Using GAPIT
Jiabo Wang, You Tang, and Zhiwu Zhang
14. Performing Genome-Wide Association Studies Using rMVP
Xiaolei Liu, Lilin Yin, Haohao Zhang, Xinyun Li, and Shuhong Zhao
Part V: Identification of Candidate Genes and Validation
15. Identification and Validation of Candidate Genes from Genome-Wide Association Studies
Elise Albert and Christopher Sauvage
16. Biparental Crossing and QTL Mapping for Genome-Wide Association Studies Validation
Pawan L. Kulwal and Ravinder Singh
17. Development of Breeder Friendly KASP Markers from Genome-Wide Association Studies Results
Manar Makhoul and Christian Obermeier
Part VI: Case Studies
18. Mapping Major Disease Resistance Genes in Soybean by Genome-Wide Association Studies
Everton Geraldo Capote Ferreira and Francismar Correa Marcelino-Guimaraes
19. GWAS Case Studies in Wheat
Deepmala Sehgal and Susanne Dreisigacker
20. Plant Microbiome-Based Genome-Wide Association Studies
Siwen Deng, Michael A. Meier, Daniel Caddell, Jinliang Yang, and Devin Coleman-Derr
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