Epigenetics in organ specific disorders
Author(s)
Bibliographic Information
Epigenetics in organ specific disorders
(Translational epigenetics series, 34)
Academic Press, c2023
- :pbk.
Available at 1 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth.
Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies.
Table of Contents
1. Introduction to epigenetic mechanisms
2. Epigenetic signatures that maintain stemness in pluripotent and mesenchymal stem cells
3. Cell-cell and Cell-matrix interactions mediated by histone deacetylases
4. Enhanced cell proliferation and altered gene expression due to actions of DNA methyltransferases
5. Histone deacetylases and regulation of gene expression during cell proliferation
6. Epigenetic mediators that promote cytoskeletal reorganization and cell migration
7. Inhibition of cellular apoptosis and senescence by unique epigenetic proteins
8. Epigenetic mechanisms involved in the regulation of necrosis and pyknosis
9. Epigenetic control over cell division in pathological conditions
10. Regulated expression of tumor suppressor proteins by DNA methyltransferases during cell cycle progression
11. Role of histone deacetylases in regulating cell cycle progression
12. Phenotype switch and cell differentiation in immune and non-immune cells regulated by different epigenetic mediators
13. Epigenetic pathways that promote cellular autophagy
14. Epigenetic inducers of Cell growth and survival
15. Microbial compounds as potential inducers of epigenetic mechanisms during infections
16. Current epigenetic drugs and their target proteins with potential use in disease treatment
17. Prospects of epigenetic drugs in combination therapy
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